hh AGK 2 (CAS 304896-28-4): R&D Systems
Catalog Number: 3233
Chemical Name: 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Biological Activity
Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
Technical Data
  • M.Wt:
    434.27
  • Formula:
    C23H13Cl2N3O2
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    304896-28-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease.
    Outeiro et al.
    Science, 2007;317:516
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AGK 2 include:

3 Citations: Showing 1 - 3
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  1. Is SIRT2 required for necroptosis?
    Authors: Newton Et al.
    Nature 2014;506:E4
  2. Temporal analysis of protein lysine acetylation during adipocyte differentiation.
    Authors: Xu Et al.
    J Pharmacol Exp Ther 2013;2:33
  3. Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
    Authors: Snider Et al.
    Adipocyte 2013;200:241

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