Chemical Name: 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Biological ActivitySelective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease.
Outeiro et al.
Citations for AGK 2
The citations listed below are publications that use Tocris products. Selected citations for AGK 2 include:
3 Citations: Showing 1 - 3
Is SIRT2 required for necroptosis?
Authors: Newton Et al.
Temporal analysis of protein lysine acetylation during adipocyte differentiation.
Authors: Xu Et al.
J Pharmacol Exp Ther 2013;2:33
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
Authors: Snider Et al.
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