Home / Class III Histone Deacetylases Inhibitors / AGK 2

AGK 2

Catalog #: 3233
3 Citations Datasheet / COA / SDS

Discontinued Product

3233 has been discontinued.
View all Class III Histone Deacetylases Inhibitors products.
AGK 2 | CAS No. 304896-28-4 | Class III Histone Deacetylases Inhibitors
1 Image
Description: Selective SIRT2 inhibitor

Chemical Name: 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.

Technical Data

M.Wt:
434.27
Formula:
C23H13Cl2N3O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
304896-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Is SIRT2 required for necroptosis?
    Newton K, Hildebrand J, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger D, Huang C, Auwerx J, Vandenabeele P, Green D, Ashkenazi A, Dixit V, Kaiser W, Strasser A, Degterev A, Silke J
    Nature, 2014;506(7489):E4-6.
  2. Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease.
    Outeiro et al.
    Science, 2007;317:516

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

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Citations for AGK 2

The citations listed below are publications that use Tocris products. Selected citations for AGK 2 include:

3 Citations: Showing 1 - 3

  1. Is SIRT2 required for necroptosis?
    Authors: Newton Et al.
    Nature  2014;506:E4
  2. Temporal analysis of protein lysine acetylation during adipocyte differentiation.
    Authors: Xu Et al.
    J Pharmacol Exp Ther  2013;2:33
  3. Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
    Authors: Snider Et al.
    Adipocyte  2013;200:241

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