Selective inhibitor of SIRT2 (IC50
= 3.5 μ
M). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μ
M. Reduces α
-synuclein-mediated toxicity in in vitro
and in vivo
models of Parkinson's disease.
Soluble to 10 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease.
Outeiro et al.
The citations listed below are publications that use Tocris products. Selected citations for AGK 2 include:
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