Catalog Number: 6161
Chemical Name: (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
Biological Activity
Potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo. Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.
Technical Data
  • M.Wt:
    376.4
  • Formula:
    C20H24O7
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    981-15-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ailanthone inhibits Huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo.
    Zhuo et al.
    Sci.Rep., 2015;5:16185
  2. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer.
    He et al.
    Nat.Commun., 2015;7:13122
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