Chemical Name: cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic (4→8)-sulfide (R)-S-oxide
Biological ActivityInhibitor of RNA polymerase II. Inhibits transcription in eukaryotic cells. Binds and blocks the largest subunits of RNA polymerase II, preventing new ribonucleotides from incorporating into the nascent RNA chain. Potent amatoxin.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The transcriptional inhibitors, actinomycin D and α-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain.
Casse et al.
Close association of RNA polymerase II and many transcription factors with Pol III genes.
Raha et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for α-Amanitin
Average Rating: 5 (Based on 1 Review)
Have you used α-Amanitin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
alpha -Amanitin was used in antibacterial resistance experiments.We looked into RNAP translocation along the DNA without dissociating from either the template or the growing RNA product until it encounters a termination factor or signal that causes the transcription cycle end with dissociation of the transcribing complex and release of RNA polymerase for a new round of transcription.