α-Amanitin

Catalog # Availability Size / Price Qty
4025/1
4025/5
RNA/DNA Polymerase Inhibitors Small Molecule
1 Image
Description: Inhibitor of RNA polymerase II

Chemical Name: cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic (4→8)-sulfide (R)-S-oxide

Purity: ≥95%

Product Details
Reviews (1)

Biological Activity

Inhibitor of RNA polymerase II. Inhibits transcription in eukaryotic cells. Binds and blocks the largest subunits of RNA polymerase II, preventing new ribonucleotides from incorporating into the nascent RNA chain. Potent amatoxin.

Technical Data

M.Wt:
918.97
Formula:
C39H54N10O14S
Solubility:
Soluble to 5 mM in ethanol and to 5 mM in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
23109-05-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The transcriptional inhibitors, actinomycin D and α-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain.
    Casse et al.
    J.Biol.Chem., 1999;274:16097
  2. Close association of RNA polymerase II and many transcription factors with Pol III genes.
    Raha et al.
    Proc.Natl.Acad.Sci., 2010;107:3639

Product Datasheets

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alpha -Amanitin was used in antibacterial resistance experiments
By Anonymous on 02/20/2019
Species: Human

alpha -Amanitin was used in antibacterial resistance experiments.We looked into RNAP translocation along the DNA without dissociating from either the template or the growing RNA product until it encounters a termination factor or signal that causes the transcription cycle end with dissociation of the transcribing complex and release of RNA polymerase for a new round of transcription.


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