Biological Activityα-Bungarotoxin is a neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and > 3 μM respectively).
(Modifications: Disulfide bridge between 3 - 23, 16 - 44, 29 - 33, 48 - 59, 60 - 65)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels.
Zhang et al.
Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers.
Lopez et al.
Citations for α-Bungarotoxin
The citations listed below are publications that use Tocris products. Selected citations for α-Bungarotoxin include:
28 Citations: Showing 1 - 10
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.
Authors: Noviello Et al.
Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells.
Authors: Durham Et al.
Sci Rep 2019;9:3805
M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
Authors: Zhang Et al.
Cell Rep 2019;27:2871
α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin.
Authors: Cao Et al.
Front Immunol 2019;10:1063
Zebrafish Differentially Process Color across Visual Space to Match Natural Scenes.
Authors: Zimmermann Et al.
Curr Biol 2018;28:2018
Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.
Authors: Morris Et al.
BMC Dev Biol 2018;18:13
α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis.
Authors: Cortes Et al.
Sci Rep 2017;7:10645
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
Authors: Miyamoto Et al.
J Neurosci 2016;291:1719
The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors.
Authors: Chatzidaki Et al.
PLoS One 2015;97:75
NE is required to promote wakefulness and for hypocretin-induced arousal in zebrafish.
Authors: Singh Et al.
Novel aspects of cholinergic regulation of colonic ion transport.
Authors: Bader and Diener
J Biol Chem 2015;3:e00139
Selective Gating of Neuronal Activity by Intrinsic Properties in Distinct Motor Rhythms.
Cholinergic control of γ power in the midbrain spatial attention network.
Authors: Bryant Et al.
Proc Natl Acad Sci U S A 2015;35:761
Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.
Authors: Gill-Thind Et al.
J Biol Chem 2015;290:3552
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.
Authors: Spurny Et al.
Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption.
Authors: Ślimak Et al.
Front Hum Neurosci 2014;8:12
The α 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes.
Authors: Macpherson Et al.
J Neurosci 2014;63:557
Optogenetic and pharmacologic dissection of feedforward inhibition in Drosophila motion vision.
Authors: Mauss Et al.
J Neurosci 2014;34:2254
Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
Authors: Zhong Et al.
Pharmacol Res Perspect 2013;8:e82719
Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor.
Authors: Némethova Et al.
Inflamm Res 2013;8:e79264
Fast silencing reveals a lost role for reciprocal inhibition in locomotion.
Authors: Moult Et al.
Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity.
Authors: Kamynina Et al.
Int J Biochem Cell Biol 2013;45:899
Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Authors: Garção Et al.
Br J Pharmacol 2013;169:1600
CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation.
Authors: Sala Et al.
Br J Pharmacol 2013;168:835
CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression.
Authors: Krais Et al.
Skeletal muscle IP3R1 receptors amplify physiological and pathological synaptic calcium signals.
Authors: Zhu Et al.
J Neurosci 2011;31:15269
Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
Authors: Demarque and Spitzer
Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.
Authors: Sun Et al.
Mol Cancer Ther 2009;8:110
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