Biological ActivityNeurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and > 3 μM respectively).
(Modifications: Disulfide bridge between 3 - 23, 16 - 44, 29 - 33, 48 - 59, 60 - 65)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels.
Zhang et al.
Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers.
Lopez et al.
Citations for α-Bungarotoxin
The citations listed below are publications that use Tocris products. Selected citations for α-Bungarotoxin include:
27 Citations: Showing 1 - 10
Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells.
Authors: Durham Et al.
Sci Rep 2019;9:3805
M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
Authors: Zhang Et al.
Cell Rep 2019;27:2871
α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin.
Authors: Cao Et al.
Front Immunol 2019;10:1063
Zebrafish Differentially Process Color across Visual Space to Match Natural Scenes.
Authors: Zimmermann Et al.
Curr Biol 2018;28:2018
Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.
Authors: Morris Et al.
BMC Dev Biol 2018;18:13
α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis.
Authors: Cortes Et al.
Sci Rep 2017;7:10645
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
Authors: Miyamoto Et al.
J Neurosci 2016;291:1719
The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors.
Authors: Chatzidaki Et al.
PLoS One 2015;97:75
NE is required to promote wakefulness and for hypocretin-induced arousal in zebrafish.
Authors: Singh Et al.
Novel aspects of cholinergic regulation of colonic ion transport.
Authors: Bader and Diener
J Biol Chem 2015;3:e00139
Selective Gating of Neuronal Activity by Intrinsic Properties in Distinct Motor Rhythms.
Cholinergic control of γ power in the midbrain spatial attention network.
Authors: Bryant Et al.
Proc Natl Acad Sci U S A 2015;35:761
Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.
Authors: Gill-Thind Et al.
J Biol Chem 2015;290:3552
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.
Authors: Spurny Et al.
Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption.
Authors: Ślimak Et al.
Front Hum Neurosci 2014;8:12
The α 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes.
Authors: Macpherson Et al.
J Neurosci 2014;63:557
Optogenetic and pharmacologic dissection of feedforward inhibition in Drosophila motion vision.
Authors: Mauss Et al.
J Neurosci 2014;34:2254
Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
Authors: Zhong Et al.
Pharmacol Res Perspect 2013;8:e82719
Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor.
Authors: Némethova Et al.
Inflamm Res 2013;8:e79264
Fast silencing reveals a lost role for reciprocal inhibition in locomotion.
Authors: Moult Et al.
Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity.
Authors: Kamynina Et al.
Int J Biochem Cell Biol 2013;45:899
Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Authors: Garção Et al.
Br J Pharmacol 2013;169:1600
CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation.
Authors: Sala Et al.
Br J Pharmacol 2013;168:835
CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression.
Authors: Krais Et al.
Skeletal muscle IP3R1 receptors amplify physiological and pathological synaptic calcium signals.
Authors: Zhu Et al.
J Neurosci 2011;31:15269
Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
Authors: Demarque and Spitzer
Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.
Authors: Sun Et al.
Mol Cancer Ther 2009;8:110
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
VersaClone cDNA Plasmids
Reviews for α-Bungarotoxin
There are currently no reviews for this product. Be the first to review α-Bungarotoxin and earn rewards!
Have you used α-Bungarotoxin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image