Biological Activityα-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist.
(Modifications: Phe-37 = C-terminal amide, Disulfide bridge: 2-7)
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International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors.
Poyner et al.
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in in vitro study (Hek 293 cells), stimulate CGRP Receptor (CLR) on the plasma membrane causing internalization.