α-CGRP (human)

Tocris Bioscience | Catalog # 3012

CGRP agonist
Tocris Bioscience

Key Product Details

Description

CGRP agonist
View all Calcitonin and Related Receptor Agonists »

Product Description

α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. It is a long-lasting vasodilator. α-CGRP (human) also reduces the secretion of both mouse Ins1 and Ins2 proteins and remodels amylin fibrillization in mouse pancreatic β-cells.

Product Specifications for α-CGRP (human)

Molecular Weight

3789.33

Formula

C163H267N51O49S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

90954-53-3

PubChem ID

44563440

InChI Key

JMJJWZFCOWFIBU-XJVRLEFXSA-N

SMILES

[H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 0.5mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for α-CGRP (human)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for α-CGRP (human)

For research use only

Citations for α-CGRP (human)

Customer Reviews for α-CGRP (human) (1)

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  • Potent CGRP agonist
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hek 293 Cells
    Verified Customer | Posted 09/20/2019
    Easy to dissolve in DMSO, stock solution concentration 10mM.
    in in vitro study (Hek 293 cells), stimulate CGRP Receptor (CLR) on the plasma membrane causing internalization.

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