Catalog Number: 3119
Biological Activity
Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2, α3β2, α4β2, α2β4, α3β3 and α4β4 subunit combinations.
Technical Data
  • M.Wt:
    1351.6
  • Formula:
    C52H78N20O15S4
  • Sequence:
    GCCSDPRCAWRC

    (Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12)

  • Solubility:
    Soluble to 1 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
    156467-85-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
  1. A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI.
    McIntosh et al.
    J.Biol.Chem., 1994;269:16733
  2. α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors.
    Johnson et al.
    Mol.Pharmacol., 1995;48:194
  3. α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.
    Pereira et al.
    J.Pharmacol.Exp.Ther., 1996;278:1472

Have you used α-Conotoxin ImI?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information