Catalog Number: 1184
Alternate Names: α-helical-Corticotropin-Releasing Factor 9-41
Biological Activity
Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).
Technical Data
  • M.Wt:
    3827
  • Formula:
    C166H274N46O53S2
  • Sequence:
    DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA

    (Modifications: Ala-33 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 0.1% TFA
  • Storage:
    Desiccate at -20°C
  • CAS No:
    90880-23-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the SALK Institute
Background References
  1. Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226.
    Kask et al.
    NeuroReport, 1997;8:3645
  2. Corticotropin releasing factor receptors and their ligand family.
    Perrin and Vale
    Ann.N.Y.Acad.Sci., 1999;885:312
  3. Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41).
    Swerdlow et al.
    Neuropsychopharmacology, 1989;2:285
Citations:

The citations listed below are publications that use Tocris products. Selected citations for α-helical CRF 9-41 include:

1 Citations: Showing 1 - 1

  1. Role of nesfatin-1 in a rat model of visceral hypersensitivity.
    Authors: Jia Et al.
    J Immunol 2013;19:3487

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