α-Mangostin

Tocris Bioscience | Catalog # 6856

Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
Tocris Bioscience
Discontinued Product
6856 has been discontinued. View all Cancer Stem Cells products.

Key Product Details

Description

Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
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Product Description

α-Mangostin is a xanthone derivative. Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines. Also suppresses the invasive and metastatic ability of pancreatic CSCs by modulation of cadherin expression and suppressing the transcription factors Snail and Slug. Attenuates the expression of Nanog and pluripotency promoting transcription factors, and inhibits Nanog binding. Downregulates the PI 3-K/Akt pathway. Inhibits self-renewal of CSCs isolated from human primary tumors and KrasG12D mice. Inhibits MRSA and VRE. Antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic, anti-inflammatory, antioxidant and neuroprotective.

Product Specifications for α-Mangostin

Molecular Weight

410.47

Formula

C24H26O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

CAS Number

6147-11-1

PubChem ID

5281650

InChI Key

GNRIZKKCNOBBMO-UHFFFAOYSA-N

SMILES

COC1=C(CC=C(C)C)C2=C(OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.05 100
Ethanol 41.05 100

Preparing Stock Solutions for α-Mangostin

The following data is based on the product molecular weight 410.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for α-Mangostin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for α-Mangostin

For research use only

Customer Reviews for α-Mangostin (1)

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  • Anti-diabetic study employing alpha -Mangostin
    Name: Joe Ques
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 04/26/2024
    alpha -mangostin at a concentration between 100-300 µg/ml used to understand insulin secretion change
    Studied the anti-diabetic effects of alpha mangostin. The product performed well under study conditions and produced reproducible results.
    α-Mangostin 6856

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