Catalog Number: 2584
Alternate Names: α-Melanotropin, α-Melanocyte-stimulating hormone
Biological Activity
Endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)

  • Solubility:
    Soluble to 0.60 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Melanocortin receptors: perspectives for novel drugs.
    Eur.J.Pharmacol., 1999;375:295
  2. Alpha-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat.
    Mizusawa et al.
    J.Urol., 2002;167:757
  3. Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure.
    Yamaoka-Tojo et al.
    Intern.Med., 2006;45:429

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