Biological ActivityEndogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.
(Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Melanocortin receptors: perspectives for novel drugs.
Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure.
Yamaoka-Tojo et al.
Alpha-melanocyte stimulating hormone and oxyt. induced penile erections, and intracavernous pressure increases in the rat.
Mizusawa et al.
Citations for α-MSH
The citations listed below are publications that use Tocris products. Selected citations for α-MSH include:
2 Citations: Showing 1 - 2
Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
Authors: Nepomuceno Et al.
Front Pharmacol 2018;9:157
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
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