Alrestatin

Key Product Details

Product Description

Alrestatin is a specific inhibitor of aldose reductase (IC₅₀ = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.

Product Specifications for Alrestatin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Alrestatin

The following data is based on the product molecular weight 255.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.92 mL	19.59 mL	39.18 mL
5 mM	0.78 mL	3.92 mL	7.84 mL
10 mM	0.39 mL	1.96 mL	3.92 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ehrig Mechanism of aldose reductase inhibition: binding of NADP⁺/NADPH and alrestatin-like inhibitors. Biochemistry 1994 PMID: 8003482
• Lavrentyev Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 2007 PMID: 17626897
• Barski The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 1996 PMID: 8916913

Product Documents for Alrestatin