Catalog Number: 0485
Chemical Name: 1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-acetic acid
Biological Activity
Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
Technical Data
  • M.Wt:
    255.23
  • Formula:
    C14H9NO4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    51411-04-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.
    Barski et al.
    Biochemistry, 1996;35:14276
  2. Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.
    Ehrig et al.
    Biochemistry, 1994;33:7157
  3. Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells.
    Lavrentyev et al.
    Circ.Res., 2007;101:455
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Alrestatin include:

3 Citations: Showing 1 - 3
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  1. Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells.
    Authors: Mochin Et al.
    PLoS One 2015;97:55
  2. The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions.
    Authors: Bresson Et al.
    Front Pharmacol 2012;3:98
  3. High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs.
    Authors: Lavrentyev and Malik
    Am J Physiol Heart Circ Physiol 2009;296:H106

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