Specific inhibitor of aldose reductase (IC50
= 148 μ
M). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro
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The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.
Barski et al.
Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.
Ehrig et al.
Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells.
Lavrentyev et al.
The citations listed below are publications that use Tocris products. Selected citations for Alrestatin include:
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