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AM 2394

Catalog #: 6034 Datasheet / COA / SDS

Discontinued Product

6034 has been discontinued.
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AM 2394 | CAS No. 1442684-77-6 | Hexokinase Activators
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Description: Potent glucokinase activator; orally bioavailable

Chemical Name: N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea

Purity: ≥98%

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Biological Activity

AM 2394 is a potent glucokinase activator (EC50 = 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.

Technical Data

M.Wt:
423.47
Formula:
C22H25N5O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1442684-77-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel series of potent glucokinase activators leading to the discovery of AM-2394.
    Dransfield et al.
    ACS Med.Chem.Lett., 2016;7:714

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