Potent glucokinase activator (EC50
= 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob
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All Tocris products are intended for laboratory research use only.
Novel series of potent glucokinase activators leading to the discovery of AM-2394.
Dransfield et al.
ACS Med.Chem.Lett., 2016;7:714