AM 281

Key Product Details

Product Description

AM 281 is a potent, selective CB₁ cannabinoid receptor antagonist/inverse agonist (K_i values are 12 and 4200 nM for CB₁ and CB₂ receptors respectively). Increases locomotor activity following systemic administration in vivo. Analog of SR141716A (K_i = 14 nM).

Licensing Information

Sold with the permission of the University of Connecticut

Product Specifications for AM 281

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AM 281

The following data is based on the product molecular weight 557.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.39 mL	11.96 mL	23.93 mL
3.75 mM	0.48 mL	2.39 mL	4.79 mL
7.5 mM	0.24 mL	1.20 mL	2.39 mL
37.5 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

• Lan Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand. AAPS Pharmsci. 1999 PMID: 11741201
• Gifford Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices. Neurosci.Lett. 1997 PMID: 9464661
• Gatley Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo. J.Neurochem. 1998 PMID: 9422389
• Cosenza Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the antagonist/inverse agonist AM281. Synapse 2000 PMID: 11044895

Product Documents for AM 281