inverse agonist (K
= 31.2 nM) that displays 165-fold selectivity over CB
receptors. Behaves as a weak partial/inverse agonist at CB
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Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
Authors: Jiang Et al.
PLoS One ;2:e641
The synthetic cannabinoid WIN-55,212-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor.
Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
Authors: Huang Et al.
Scientific Reports 2016;6:29757
CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory.
Authors: Li and Kim
Mol Pharmacol 2016;2016:9817089
Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
Authors: Kruk-Slomka Et al.
Neural Plast 2016;2016:9815092
The endocannabinoid anandamide impairs in vitro decidualization of human cells.
Authors: Almada Et al.
Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.
Authors: Krohn Et al.
J Inflamm (Lond) 2016;13:21
Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors.
Authors: Blaha Et al.
PLoS One 2016;11:e0157424
Cannabinoid 2 receptor is a novel anti-inflammatory target in experimental proliferative vitreoretinopathy
Authors: Szczesniak Et al.
CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion.
Authors: Zhang Et al.
Mediators Inflamm 2015;8:3491
Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected].
Authors: Krishnan and Chatterjee
PLoS One 2015;5:9887
Cannabinoid receptor CB2 is involved in tetrahydrocannabinol-induced anti-inflammation against lipopolysaccharide in MG-63 cells.
Authors: Yang Et al.
PLoS One 2015;2015:362126
Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
Authors: Malek Et al.
Neural Plast 2015;2015:130639
Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent.
Authors: Borrelli Et al.
Sci Rep 2015;172:142
Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice.
Authors: Verty Et al.
PLoS One 2015;10:e0140592
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Authors: Smith Et al.
Neural Plast 2015;10:e0136546
Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation.
Authors: Savonenko Et al.
PLoS One 2015;10:e0129618
High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets.
Authors: Woolcott Et al.
Br J Pharmacol 2015;10:e0123558
Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
Authors: Stanley Et al.
Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms.
Authors: Raver and Keller
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
Authors: Alpár Et al.
Pharmacol Res 2014;5:4421
Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
Authors: Sardinha Et al.
Treatment with a cannabinoid receptor 2 agonist decreases severity of established cystitis.
Authors: Wang Et al.
Br J Pharmacol 2014;191:1153
Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine.
Authors: Machado Et al.
Br J Pharmacol 2014;171:961
Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes.
Authors: Kury Et al.
Br J Pharmacol 2014;171:3485
Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis.
Authors: Toguri Et al.
PLoS One 2014;171:1448
2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells.
Authors: Costa Et al.
Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice.
Authors: Costola-de-Souza Et al.
PLoS One 2013;8:e77706
Deriving dopaminergic neurons for clinical use. A practical approach.
Authors: Gonzalez Et al.
Sci Rep 2013;3:1463
Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury.
Authors: Tchantchou and Zhang
J Neurotrauma 2013;30:565
Activation of cannabinoid receptor 2 inhibits experimental cystitis.
Authors: Wang Et al.
Br J Pharmacol 2013;304:R846
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain.
Authors: Uhelski Et al.
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
Authors: Li Et al.
Br J Pharmacol 2013;170:489
Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
Authors: Marini Et al.
Br J Pharmacol 2013;169:887
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Authors: Sreevalsan and Safe
Mol Cancer Ther 2013;12:2483
Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
Authors: Guida Et al.
Mol Pain 2012;8:60
Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.
Authors: Arévalo-Martín Et al.
Mol Pharmacol 2012;7:e49057
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
Authors: Tauber Et al.
PLoS One 2012;7:e48272
Tricyclic Pyrazoles. Part 5. Novel 1,4-Dihydroindeno[1,2-c]pyrazole CB2 Ligands Using Molecular Hybridization Based on Scaffold Hopping.
Authors: Murineddu Et al.
Open Med Chem J 2012;6:1
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
Authors: Tumati Et al.
J Neuroimmunol 2012;244:23
A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease.
Authors: Piro Et al.
Eur J Pharmacol 2012;1:617
Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors.
Authors: García-Gutiérrez Et al.
Br J Pharmacol 2012;165:951
Cannabinoid CB? receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice.
Authors: Navarrete Et al.
Br J Pharmacol 2012;165:260
AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
Authors: Bolognini Et al.
Br J Pharmacol 2012;165:2561
Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.
Authors: Merighi Et al.
Br J Pharmacol 2012;165:1773
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice.
Authors: Bashashati Et al.
Br J Pharmacol 2012;165:1556
Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
Authors: Niu Et al.
Br J Pharmacol 2012;153:2283
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Authors: Liu Et al.
Mol Cancer Ther 2012;11:1421
The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
Authors: Negrete Et al.
PLoS One 2011;6:e26688
Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain.
Authors: Khasabova Et al.
FASEB J 2011;64:60
Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy.
Authors: Barutta Et al.
Perinatal exposure to δ9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens.
Authors: Lombard Et al.
J Pharmacol Exp Ther 2011;339:607
β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway.
Authors: Bento Et al.
Am J Pathol 2011;178:1153
THC Prevents MDMA Neurotoxicity in Mice.
Authors: Touriño Et al.
PLoS One 2010;5:e9143
Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain.
Authors: Alkaitis Et al.
PLoS One 2010;5:e10891
The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages.
Authors: Hao Et al.
J Leukoc Biol 2010;51:2181
The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice.
Authors: Hervera Et al.
J Pharmacol Exp Ther 2010;334:887
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Authors: Buznikov Et al.
Neurobiol Dis 2010;32:43101
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
Authors: Brown Et al.
Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.
Authors: Schuelert Et al.
Osteoarthritis Cartilage 2010;18:1536
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Authors: Mair Et al.
Br J Pharmacol 2010;161:176
Endocannabinoid involvement in endometriosis.
Authors: Dmitrieva Et al.
CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages.
Authors: Han Et al.
Cardiovasc Res 2009;84:378
Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.
Authors: Deveaux Et al.
Am J Physiol Regul Integr Comp Physiol 2009;4:e5844
The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.
Authors: Meuth Et al.
Am J Physiol Heart Circ Physiol 2009;33:42675
The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy.
Authors: Defer Et al.
PLoS One 2009;23:2120
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Authors: Pacheco Et al.
Br J Pharmacol 2009;158:225
Endogenous cannabinoids induce fever through the activation of CB1 receptors.
Authors: Fraga Et al.
Mediators Inflamm 2009;157:1494
Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes.
Authors: Börner Et al.
Br J Pharmacol 2008;73:1013
Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
Authors: Desroches Et al.
J Lipid Res 2008;155:913
CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration.
Authors: Rajesh Et al.
Br J Pharmacol 2008;153:347
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms.
Authors: Potenzieri Et al.
Brain Res 2008;1215:69
Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis.
Authors: Rajesh Et al.
Cardiovasc Res 2007;82:1382
The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
Authors: Saitoh Et al.
J Cell Biol 2007;570:182
Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
Authors: Mukhopadhyay Et al.
J Am Coll Cardiol 2007;50:528
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.
Authors: Bátkai Et al.
Int J Clin Exp Pathol 2007;293:H909
Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.
Authors: Rajesh Et al.
Am J Physiol Heart Circ Physiol 2007;293:H610
CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
Authors: Rajesh Et al.
Am J Physiol Heart Circ Physiol 2007;293:H2210
Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats.
Authors: Ghasemi Et al.
Br J Pharmacol 2007;151:591
Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
Authors: Börner Et al.
Cell Rep 2006;69:1486
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
Authors: Moezi Et al.
Dev Neurosci 2006;149:898
Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
Authors: Gaskari Et al.
Nat Commun 2005;146:315
Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
Authors: Price Et al.
Br J Pharmacol 2004;142:257
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Authors: Mathison Et al.
Br J Pharmacol 2004;142:1247
The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
Authors: Williams Et al.
J Urol 2003;160:481
Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts.
Authors: Ford Et al.
Br J Pharmacol 2002;135:1191
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