Catalog Number: 0876
Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride
Biological Activity
A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.
Technical Data
  • M.Wt:
    483.84
  • Formula:
    C19H24Cl2N2O4S.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    133229-11-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016.
    Hagerty et al.
    J.Pharm.Pharmacol., 1996;48:417
  2. Inhibition by compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells.
    Lei and Brown
    Naunyn Schmiedebergs Arch.Pharmacol., 1998;357:260
  3. Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells.
    Palen et al.
    Cardiovasc.Res., 2005;68:268
  4. Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells.
    Conners et al.
    Br.J.Pharmacol., 1992;106:958

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