AM 92016 hydrochloride
Discontinued Product
Chemical Name: 1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride
Purity: ≥98%
Biological Activity
A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016.
Hagerty et al.
J.Pharm.Pharmacol., 1996;48:417 -
Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells.
Palen et al.
Cardiovasc.Res., 2005;68:268 -
Actions and mechanisms of action of novel analogues of sot. on guinea-pig and rabbit ventricular cells.
Conners et al.
Br.J.Pharmacol., 1992;106:958 -
Inhibition by compound II, a sot. analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells.
Lei and Brown
Naunyn Schmiedebergs Arch.Pharmacol., 1998;357:260
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