A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β
-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo
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The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016.
Hagerty et al.
Inhibition by compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells.
Lei and Brown
Naunyn Schmiedebergs Arch.Pharmacol., 1998;357:260
Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells.
Palen et al.
Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells.
Conners et al.