(±)-Anatoxin A fumarate
Chemical Name: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate
Biological Activity(±)-Anatoxin A fumarate is a potent nicotinic agonist (Ki values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). (�)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50 = 136 nM). (�)-Anatoxin A fumarate induces apoptosis in rat thymocytes and Vero cells by generation of reactive oxygen species and caspase activation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A.
Gordon et al.
UB-165 implicates α4β2 nAChR in striatal DA release.
Sharples et al.
Behavioural effects of anatoxin, a potent nicotinic agonist in rats.
Stolerman et al.
(+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors.
Thomas et al.
Citation for (±)-Anatoxin A fumarate
The citations listed below are publications that use Tocris products. Selected citations for (±)-Anatoxin A fumarate include:
1 Citation: Showing 1 - 1
Effect of nitrogen on cellular production and release of the neurotoxin anatoxin-a in a nitrogen-fixing cyanobacterium.
Authors: Gagnon and Pick
Front Microbiol 2012;3:211
Why is fumarate included in the formulation?
Fumarate salt confers water solubility of the (±)-Anatoxin A.
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