KIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50
= 175 nM). Caspase-dependant apoptosis inducer.
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Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells.
Faderl et al.
Cancer Res., 2009;69:3910