Apicidin
Discontinued Product
Chemical Name: Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
Purity: ≥98%
Biological Activity
Potent histone deacetylase (HDAC) inhibitor (IC50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.
Han et al.
Cancer Res., 2000;60:6068 -
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
Darkin-Rattray et al.
Proc.Natl.Acad.Sci., 1996;93:13143 -
Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells.
Ahn et al.
Oral Oncol., 2011;47:1032 -
Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials.
Kim et al.
Biochem.Biophys.Res.Comm., 2004;19:964
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