Catalog Number: 4846
Chemical Name: Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
Biological Activity
Potent histone deacetylase (HDAC) inhibitor (IC50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.
Technical Data
  • M.Wt:
    623.78
  • Formula:
    C34H49N5O6
  • Solubility:
    Soluble to 2 mM in DMSO and to 2 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    183506-66-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.
    Han et al.
    Cancer Res., 2000;60:6068
  2. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
    Darkin-Rattray et al.
    Proc.Natl.Acad.Sci., 1996;93:13143
  3. Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells.
    Ahn et al.
    Oral Oncol., 2011;47:1032
  4. Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials.
    Kim et al.
    Biochem.Biophys.Res.Comm., 2004;19:964

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