Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50
values are 59.44 and 31.15 μ
M at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo
Soluble to 50 mM in DMSO
Desiccate at +4°C
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All Tocris products are intended for laboratory research use only.
Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells.
Choi et al.
Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress.
Jin et al.
Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin.
Lin et al.
Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.
Kuo and Yang
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells.
Sato et al.
The citations listed below are publications that use Tocris products. Selected citations for Apigenin include:
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