Catalog Number: 1227
Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Biological Activity
Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.
Technical Data
  • M.Wt:
    270.2
  • Formula:
    C15H10O5
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    520-36-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells.
    Choi et al.
    J.Clin.Biochem.Nutr., 2009;44:260
  2. Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress.
    Jin et al.
    Eur.J.Pharmacol., 2009;616:200
  3. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin.
    Lin et al.
    J.Cell.Biochem.Suppl., 1997;28-29:39
  4. Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.
    Kuo and Yang
    Biochem.Biophys.Res.Commun., 1995;212:767
  5. Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells.
    Sato et al.
    Biochem.Biophys.Res.Commun., 1994;204:578
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Apigenin include:

1 Citations: Showing 1 - 1

  1. Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells.
    Authors: Lim Et al.
    J Neurosci 2006;42:3260

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