Catalog Number: 3321
Alternate Names: FPL 66096, ARL 66096
Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Biological Activity
Potent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca
Background References
  1. FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors.
    Humphries et al.
    Br.J.Pharmacol., 1994;113:1057
  2. Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy.
    Ingall et al.
    J.Med.Chem., 1999;42:213
  3. Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells.
    Simon et al.
    Br.J.Pharmacol., 2001;132:173

The citations listed below are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:

Showing Results 1 - 4 of 4

  1. Agonist-bound structure of the human P2Y12 receptor.
    Authors: Zhang Et al.
    Purinergic Signal
  2. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Cell Commun Signal
  3. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal
  4. Mechanisms of hemolysis-associated platelet activation.
    Authors: Helms Et al.
    J Thromb Haemost
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note: fgdfgsd

Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information