Catalog Number: 3321
Alternate Names: FPL 66096, ARL 66096
Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Biological Activity
Potent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
Technical Data
  • M.Wt:
    703.26
  • Formula:
    C14H18F2N5Na4O12P3S
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    145782-74-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca
Background References
  1. FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors.
    Humphries et al.
    Br.J.Pharmacol., 1994;113:1057
  2. Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy.
    Ingall et al.
    J.Med.Chem., 1999;42:213
  3. Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells.
    Simon et al.
    Br.J.Pharmacol., 2001;132:173
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Agonist-bound structure of the human P2Y12 receptor.
    Authors: Zhang Et al.
    Purinergic Signal 2014;509:119
  2. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Cell Commun Signal 2013;9:31
  3. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal 2013;11:70
  4. Mechanisms of hemolysis-associated platelet activation.
    Authors: Helms Et al.
    J Thromb Haemost 2013;11:2148

Have you used AR-C 66096 tetrasodium salt?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information