AR-C 66096 tetrasodium salt
Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Biological ActivityAR-C 66096 tetrasodium salt is a potent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors.
Humphries et al.
Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy.
Ingall et al.
Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells.
Simon et al.
Citations for AR-C 66096 tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:
7 Citations: Showing 1 - 7
The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.
Authors: Lu Et al.
Front Pharmacol 2018;9:242
Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry.
Authors: Chan Et al.
Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
Authors: Aungraheeta Et al.
Agonist-bound structure of the human P2Y12 receptor.
Authors: Zhang Et al.
Purinergic Signal 2014;509:119
The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
Authors: Gao Et al.
Cell Commun Signal 2013;9:31
Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
Authors: Pinheiro Et al.
Cell Commun Signal 2013;11:70
Mechanisms of hemolysis-associated platelet activation.
Authors: Helms Et al.
J Thromb Haemost 2013;11:2148
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