AR-C 66096 tetrasodium salt
Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Biological ActivityPotent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors.
Humphries et al.
Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy.
Ingall et al.
Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells.
Simon et al.
Citations for AR-C 66096 tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:
7 Citations: Showing 1 - 7
The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.
Authors: Lu Et al.
Front Pharmacol 2018;9:242
Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry.
Authors: Chan Et al.
Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
Authors: Aungraheeta Et al.
Agonist-bound structure of the human P2Y12 receptor.
Authors: Zhang Et al.
Purinergic Signal 2014;509:119
The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
Authors: Gao Et al.
Cell Commun Signal 2013;9:31
Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
Authors: Pinheiro Et al.
Cell Commun Signal 2013;11:70
Mechanisms of hemolysis-associated platelet activation.
Authors: Helms Et al.
J Thromb Haemost 2013;11:2148
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