AR-C 66096 tetrasodium salt

  ( 5 citations )    
Product Datasheet
Catalog Number:3321
Alternate Names:FPL 66096, ARL 66096
Chemical Name:2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
Potent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
Technical Data
  • M.Wt:
    703.26
  • Formula:
    C14H18F2N5Na4O12P3S
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    145782-74-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:

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  1. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
    Authors: Aungraheeta Et al.
    Blood  2016;128:2717
  2. Agonist-bound structure of the human P2Y12 receptor.
    Authors: Zhang Et al.
    Purinergic Signal  2014;509:119
  3. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Cell Commun Signal  2013;9:31
  4. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal  2013;11:70
  5. Mechanisms of hemolysis-associated platelet activation.
    Authors: Helms Et al.
    J Thromb Haemost  2013;11:2148

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