AR-R 17779 hydrochloride
Chemical Name: (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
Biological ActivitySelective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). CNS penetrant after systemic administration.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.
Grottick et al.
(-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor.
Mullen et al.
Activation of presynaptic α7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.
Huang et al.
Citation for AR-R 17779 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AR-R 17779 hydrochloride include:
1 Citation: Showing 1 - 1
α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis.
Authors: Cortes Et al.
Sci Rep 2017;7:10645
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