Selective agonist of α
7 nAChRs (Ki
values are 190 and 16000 nM for rat α
7 and α
2 receptors respectively). CNS penetrant after systemic administration.
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Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.
Grottick et al.
(-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor.
Mullen et al.
Activation of presynaptic α7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.
Huang et al.