Arachidonyl serotonin
Discontinued Product
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
Biological Activity
Arachidonyl serotonin is a dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The endocannabinoid system and its therapeutic exploitation.
Di Marzo et al.
Nat.Rev.Drug Discov., 2004;3:771 -
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
Maione et al.
Br.J.Pharmacol., 2007;150:766 -
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.
Bisogno et al.
Biochem.Biophys.Res.Comms., 1998;248:515
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