Catalog Number: 2836
Alternate Names: AA-5-HT
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
Biological Activity
Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
Technical Data
  • M.Wt:
    462.67
  • Formula:
    C30H42N2O2
  • Solubility:
    Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
  • Storage:
    Store at -20°C
  • CAS No:
    187947-37-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
    Maione et al.
    Br.J.Pharmacol., 2007;150:766
  2. The endocannabinoid system and its therapeutic exploitation.
    Di Marzo et al.
    Nat.Rev.Drug Discov., 2004;3:771
  3. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.
    Bisogno et al.
    Biochem.Biophys.Res.Comms., 1998;248:515

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