Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50
values are 5.6 μ
M and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2
or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
Maione et al.
The endocannabinoid system and its therapeutic exploitation.
Di Marzo et al.
Nat.Rev.Drug Discov., 2004;3:771
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.
Bisogno et al.