ARL 67156 trisodium salt

  ( 19 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1283
Alternate Names:FPL 67156
Chemical Name:6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt
Product Details
Citations (19)
Reviews
Biological Activity
Selective NTPDase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively).
Technical Data
  • M.Wt:
    785.06
  • Formula:
    C15H21Br2N5O12P3.3Na
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    1021868-83-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ARL 67156 trisodium salt include:

19 Citations: Showing 1 - 10
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  1. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.
    Authors: Conley
    PLoS One  2017;12(11):e0187481
  2. Expression of CD39 on activated T cells impairs their survival in older individuals.
    Authors: Fang Et al.
    Cell Rep.  2016;14:1218
  3. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
    Authors: Wang Et al.
    J Clin Invest  2016;126:4527
  4. A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.
    Authors: Billaud Et al.
    J Neuroimmune Pharmacol  2015;8:ra17
  5. Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.
    Authors: Acton and Miles
    Sci Signal  2015;10:e0134488
  6. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
    Authors: Ziemlinska Et al.
    PLoS One  2014;9:e88833
  7. Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation.
    Authors: Hennel Et al.
    Proc Natl Acad Sci U S A  2014;9:85
  8. Ligand-gated purinergic receptors regulate HIV-1 Tat and morphine related neurotoxicity in primary mouse striatal neuron-glia co-cultures.
    Authors: Sorrell and Hauser
    Radiat Oncol  2014;9:233
  9. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits  2014;8:60
  10. Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.
    Authors: Boyd-Tressler Et al.
    J Biol Chem  2014;289:27246
  11. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
    Authors: Carneiro Et al.
    Br J Pharmacol  2014;171:3404
  12. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci  2014;127:4964
  13. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    PLoS One  2013;305:F396
  14. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
    Authors: Ashpole Et al.
    J Biol Chem  2013;288:14599
  15. ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.
    Authors: Jansen Et al.
    Sci Rep  2013;110:20206
  16. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
    Authors: Yegutkin Et al.
    FASEB J  2012;26:3875
  17. Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
    Authors: Griffiths Et al.
    PLoS One  2011;6:e23463
  18. ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks.
    Authors: Lörincz Et al.
    PLoS One  2009;4:e4447
  19. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci  2007;27:845
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Other Experimental Details

Other Experimental Details Working concentration of 100 uM

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