ARL 67156 trisodium salt
Chemical Name: 6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt
Biological ActivityARL 67156 trisodium salt is a selective NTPDase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively). ARL 67156 prevents vascular calcification and extends longevity in Hutchinson-Gilford progeria syndrome mice. ARL 67156 increases neurogenic contract response to nerve stimulation. ARL 67156 enhances parasympathetic neurotransmission in guinea-pig urinary bladder.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase.
Crack et al.
Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ecotnucleotidases.
Levesque et al.
Release of soluble nucleotidases: a novel mechanism for neurotransmitter inactivation?
Kennedy et al.
The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea pig urinary bladder.
Westfall et al.
Citations for ARL 67156 trisodium salt
The citations listed below are publications that use Tocris products. Selected citations for ARL 67156 trisodium salt include:
24 Citations: Showing 1 - 10
Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.
Authors: Perrot Et al.
Cell Rep 2019;27:2411
ATP-based therapy prevents vascular calcification and extends longevity in a mouse model of Hutchinson-Gilford progeria syndrome.
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells.
Cell Signal 2018;51:59
Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
Authors: Kleiner Et al.
Mol Vis 2018;24:647
Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.
PLoS One 2017;12(11):e0187481
Expression of CD39 on activated T cells impairs their survival in older individuals.
Authors: Fang Et al.
Cell Rep. 2016;14:1218
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
Authors: Wang Et al.
J Clin Invest 2016;126:4527
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.
Authors: Billaud Et al.
J Neuroimmune Pharmacol 2015;8:ra17
Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.
Authors: Acton and Miles
Sci Signal 2015;10:e0134488
Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
Authors: Ziemlinska Et al.
PLoS One 2014;9:e88833
Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation.
Authors: Hennel Et al.
Proc Natl Acad Sci U S A 2014;9:85
Ligand-gated purinergic receptors regulate HIV-1 Tat and mor. related neurotoxicity in primary mouse striatal neuron-glia co-cultures.
Authors: Sorrell and Hauser
Radiat Oncol 2014;9:233
Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
Authors: Carlsen and Perrier
Front Neural Circuits 2014;8:60
Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.
Authors: Boyd-Tressler Et al.
J Biol Chem 2014;289:27246
Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
Authors: Carneiro Et al.
Br J Pharmacol 2014;171:3404
P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
Authors: Campwala Et al.
J Cell Sci 2014;127:4964
Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
Authors: Shabir Et al.
PLoS One 2013;305:F396
Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
Authors: Ashpole Et al.
J Biol Chem 2013;288:14599
ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.
Authors: Jansen Et al.
Sci Rep 2013;110:20206
Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
Authors: Yegutkin Et al.
FASEB J 2012;26:3875
Glial-derived adenosine modulates spinal motor networks in mice.
Authors: Witts Et al.
Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
Authors: Griffiths Et al.
PLoS One 2011;6:e23463
ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks.
Authors: Lörincz Et al.
PLoS One 2009;4:e4447
Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
Authors: Kennedy Et al.
J Neurosci 2007;27:845
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