Catalog Number: 1283
Alternate Names: FPL 67156
Chemical Name: 6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt
Biological Activity
Selective NTPDase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively).
Technical Data
  • M.Wt:
    785.06
  • Formula:
    C15H21Br2N5O12P3.3Na
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    1021868-83-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ecotnucleotidases.
    Levesque et al.
    Br.J.Pharmacol., 2007;152:141
  2. Release of soluble nucleotidases: a novel mechanism for neurotransmitter inactivation?
    Kennedy et al.
    TiPS, 1997;18:263
  3. The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea pig urinary bladder.
    Westfall et al.
    Eur.J.Pharmacol., 1997;329:169
  4. Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase.
    Crack et al.
    Br.J.Pharmacol., 1995;114:475
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ARL 67156 trisodium salt include:

15 Citations: Showing 1 - 10
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  1. Expression of CD39 on activated T cells impairs their survival in older individuals.
    Authors: Fang Et al.
    Cell Rep. 2016;14:1218
  2. A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.
    Authors: Billaud Et al.
    J Neuroimmune Pharmacol 2015;8:ra17
  3. Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.
    Authors: Acton and Miles
    Sci Signal 2015;10:e0134488
  4. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
    Authors: Ziemlinska Et al.
    PLoS One 2014;9:e88833
  5. Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation.
    Authors: Hennel Et al.
    Proc Natl Acad Sci U S A 2014;9:85
  6. Ligand-gated purinergic receptors regulate HIV-1 Tat and morphine related neurotoxicity in primary mouse striatal neuron-glia co-cultures.
    Authors: Sorrell and Hauser
    Radiat Oncol 2014;9:233
  7. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits 2014;8:60
  8. Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.
    Authors: Boyd-Tressler Et al.
    J Biol Chem 2014;289:27246
  9. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci 2014;127:4964
  10. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    PLoS One 2013;305:F396
  11. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
    Authors: Ashpole Et al.
    J Biol Chem 2013;288:14599
  12. ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.
    Authors: Jansen Et al.
    Sci Rep 2013;110:20206
  13. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
    Authors: Yegutkin Et al.
    FASEB J 2012;26:3875
  14. Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
    Authors: Griffiths Et al.
    PLoS One 2011;6:e23463
  15. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci 2007;27:845
Expand to show all 15 Citations

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