ARL 67156 trisodium salt

Catalog # Availability Size / Price Qty
1283/10
NTPDase Inhibitors Small Molecule
1 Image
Description: NTPDase inhibitor
Alternative Names: FPL 67156

Chemical Name: 6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt

Purity: ≥98%

Product Details
Citations (22)
Reviews (1)

Biological Activity

Selective NTPDase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively).

Technical Data

M.Wt:
785.06
Formula:
C15H21Br2N5O12P3.3Na
Solubility:
Soluble to 20 mM in water
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
1021868-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ARL 67156 trisodium salt

The citations listed below are publications that use Tocris products. Selected citations for ARL 67156 trisodium salt include:

22 Citations: Showing 1 - 10

  1. Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.
    Authors: Perrot Et al.
    Cell Rep  2019;27:2411
  2. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells.
    Authors: Ng
    Cell Signal  2018;51:59
  3. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  4. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.
    Authors: Conley
    PLoS One  2017;12(11):e0187481
  5. Expression of CD39 on activated T cells impairs their survival in older individuals.
    Authors: Fang Et al.
    Cell Rep.  2016;14:1218
  6. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
    Authors: Wang Et al.
    J Clin Invest  2016;126:4527
  7. A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.
    Authors: Billaud Et al.
    J Neuroimmune Pharmacol  2015;8:ra17
  8. Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.
    Authors: Acton and Miles
    Sci Signal  2015;10:e0134488
  9. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
    Authors: Ziemlinska Et al.
    PLoS One  2014;9:e88833
  10. Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation.
    Authors: Hennel Et al.
    Proc Natl Acad Sci U S A  2014;9:85
  11. Ligand-gated purinergic receptors regulate HIV-1 Tat and mor. related neurotoxicity in primary mouse striatal neuron-glia co-cultures.
    Authors: Sorrell and Hauser
    Radiat Oncol  2014;9:233
  12. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits  2014;8:60
  13. Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.
    Authors: Boyd-Tressler Et al.
    J Biol Chem  2014;289:27246
  14. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
    Authors: Carneiro Et al.
    Br J Pharmacol  2014;171:3404
  15. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci  2014;127:4964
  16. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    PLoS One  2013;305:F396
  17. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
    Authors: Ashpole Et al.
    J Biol Chem  2013;288:14599
  18. ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.
    Authors: Jansen Et al.
    Sci Rep  2013;110:20206
  19. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
    Authors: Yegutkin Et al.
    FASEB J  2012;26:3875
  20. Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
    Authors: Griffiths Et al.
    PLoS One  2011;6:e23463
  21. ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks.
    Authors: Lörincz Et al.
    PLoS One  2009;4:e4447
  22. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci  2007;27:845

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Prevents degradation of ATP released from cultured cells
By Anonymous on 01/10/2018
Species: Rat

Used in ATP release assay from cultured cells to inhibit ectonucleotidase function


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