Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Biological ActivityOrally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase.
Irikura et al.
Citation for AT 56
The citations listed below are publications that use Tocris products. Selected citations for AT 56 include:
1 Citation: Showing 1 - 1
Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport.
Authors: Jaurena Et al.
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