Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Biological ActivityAT 56 is an orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase.
Irikura et al.
Citation for AT 56
The citations listed below are publications that use Tocris products. Selected citations for AT 56 include:
1 Citation: Showing 1 - 1
Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport.
Authors: Jaurena Et al.
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