Orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki
= 75 μ
= 95 μ
M). Inhibits the production of PGD2
from PGH2 in vitro
, with no effect on PGE2
Soluble to 50 mM in DMSO
Store at -20°C
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Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase.
Irikura et al.
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