Atorvastatin hemicalcium salt

Tocris Bioscience | Catalog # 3776

Potent HMG-CoA reductase inhibitor
Tocris Bioscience
Discontinued Product
3776 has been discontinued. View all HMG-CoA Reductase Inhibitors products.

Key Product Details

Description

Potent HMG-CoA reductase inhibitor

Alternative Names

Lipitor
View all HMG-CoA Reductase Inhibitors »

Product Description

Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Atorvastatin hemicalcium salt

Molecular Weight

577.67

Formula

C33H34FN2O5.½Ca

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

(R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt

CAS Number

134523-03-8

PubChem ID

60822

InChI Key

FQCKMBLVYCEXJB-MNSAWQCASA-L

SMILES

[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.77 100

Preparing Stock Solutions for Atorvastatin hemicalcium salt

The following data is based on the product molecular weight 577.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.73 mL 8.66 mL 17.31 mL
5 mM 0.35 mL 1.73 mL 3.46 mL
10 mM 0.17 mL 0.87 mL 1.73 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

Product Documents for Atorvastatin hemicalcium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Atorvastatin hemicalcium salt

For research use only

Citations for Atorvastatin hemicalcium salt

Customer Reviews for Atorvastatin hemicalcium salt (1)

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  • Atorvastatin effect as Rho inhibitor
    Name: Anonymous
    Species: Bovine
    Assay Type: In Vitro
    Cell Line/Tissue: chondrocyte
    Verified Customer | Posted 03/26/2018
    used as alternative to simvastatin
    Atorvastatin hemicalcium salt 3776

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