Atorvastatin hemicalcium salt
Chemical Name: (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
Biological ActivityPotent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural mechanism for statin inhibition of HMG-CoA reductase.
Istvan et al.
Update on STAT: 2003.
Vaughan et al.
AtoVas inhibits inflammatory hypernociception.
Santodomingo-Garzon et al.
Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
Turner et al.
Citations for Atorvastatin hemicalcium salt
The citations listed below are publications that use Tocris products. Selected citations for Atorvastatin hemicalcium salt include:
2 Citations: Showing 1 - 2
AtoVas and Conditioned Media from AtoVas-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo.
Authors: Nowak Et al.
Mediators Inflamm 2019;2019:1868170
Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
Authors: Rojo-Arreola Et al.
PLoS One 2014;9:e87594
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used as alternative to simvastatin