Catalog Number: 3776
Alternate Names: Lipitor
Chemical Name: (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
Biological Activity
Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
    Turner et al.
    J.Cardiovasc.Pharmacol., 2007;50:458
  2. Atorvastatin inhibits inflammatory hypernociception.
    Santodomingo-Garzon et al.
    Br.J.Pharmacol., 2006;149:14
  3. Structural mechanism for statin inhibition of HMG-CoA reductase.
    Istvan et al.
    Science, 2001;292:1160
  4. Update on statins: 2003.
    Vaughan et al.
    Circulation, 2004;110:886
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