Atorvastatin hemicalcium salt

Discontinued Product

3776 has been discontinued.
View all HMG-CoA Reductase Inhibitors products.
Atorvastatin hemicalcium salt | CAS No. 134523-03-8 | HMG-CoA Reductase Inhibitors
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Description: Potent HMG-CoA reductase inhibitor
Alternative Names: Lipitor

Chemical Name: (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Structural mechanism for statin inhibition of HMG-CoA reductase.
    Istvan et al.
    Science, 2001;292:1160
  2. Update on STAT: 2003.
    Vaughan et al.
    Circulation, 2004;110:886
  3. AtoVas inhibits inflammatory hypernociception.
    Santodomingo-Garzon et al.
    Br.J.Pharmacol., 2006;149:14
  4. Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
    Turner et al.
    J.Cardiovasc.Pharmacol., 2007;50:458

Product Datasheets

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Citations for Atorvastatin hemicalcium salt

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Atorvastatin effect as Rho inhibitor
By Anonymous on 03/26/2018
Application: Species: Other

used as alternative to simvastatin

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