Potent HMG-CoA reductase inhibitor (IC50
= 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro
and exhibits antinociceptive effects in the inflammatory hypernociception model.
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Sold for research purposes under agreement from Pfizer Inc.
Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
Turner et al.
Atorvastatin inhibits inflammatory hypernociception.
Santodomingo-Garzon et al.
Structural mechanism for statin inhibition of HMG-CoA reductase.
Istvan et al.
Update on statins: 2003.
Vaughan et al.