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Atorvastatin hemicalcium salt

3776 2 Citations 1 Review Datasheet / COA / SDS
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Atorvastatin hemicalcium salt | CAS No. 134523-03-8 | HMG-CoA Reductase Inhibitors
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Description: Potent HMG-CoA reductase inhibitor
Alternative Names: Lipitor

Chemical Name: (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.

Technical Data

M.Wt:
577.67
Formula:
C33H34FN2O5.½Ca
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
134523-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Structural mechanism for statin inhibition of HMG-CoA reductase.
    Istvan et al.
    Science, 2001;292:1160
  2. Update on STAT: 2003.
    Vaughan et al.
    Circulation, 2004;110:886
  3. AtoVas inhibits inflammatory hypernociception.
    Santodomingo-Garzon et al.
    Br.J.Pharmacol., 2006;149:14
  4. Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
    Turner et al.
    J.Cardiovasc.Pharmacol., 2007;50:458

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Citations for Atorvastatin hemicalcium salt

The citations listed below are publications that use Tocris products. Selected citations for Atorvastatin hemicalcium salt include:

2 Citations: Showing 1 - 2

  1. AtoVas and Conditioned Media from AtoVas-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo.
    Authors: Nowak Et al.
    Mediators Inflamm  2019;2019:1868170
  2. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
    Authors: Rojo-Arreola Et al.
    PLoS One  2014;9:e87594

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Atorvastatin effect as Rho inhibitor
By Anonymous on 03/26/2018
Species: Other

used as alternative to simvastatin

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