Home / Protease-Activated Receptor Agonists / AY 254

AY 254

Catalog #: 7034 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7034/1
AY 254
1 Image
Description: Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling

Purity: ≥95%

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Biological Activity

AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.

Technical Data

M.Wt:
631.77
Formula:
C30H49N9O6
Sequence:
XXAR

(Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, Arg-4 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in 0.1% acetic acid
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2093408-03-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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AY 77
Cat # 7033

Background References

  1. Biased signaling by agonists of protease activated receptor 2.
    Jiang et al.
    ACS Chem.Biol., 2017;12:1217

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