AZ 3451

Catalog #: 6806 Datasheet / COA / SDS

Discontinued Product

6806 has been discontinued.
View all Protease-Activated Receptor Antagonists products.
AZ 3451 | CAS No. 2100284-59-9 | Protease-Activated Receptor Antagonists
1 Image
Description: Potent negative allosteric modulator of PAR2 receptors

Chemical Name: 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide

Purity: ≥98%

Product Details

Biological Activity

AZ 3451 is a potent negative allosteric modulator of PAR2 (IC50 = 23 nM); binds to a remote allosteric site outside the helical bundle. Inhibits ERK phosphorylation in 1321N1 cells overexpressing wild-type human PAR2. Highly lipophilic.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structural insight into allosteric modulation of protease-activated receptor 2.
    Cheng et al.
    Nature, 2017;545:112

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