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AZ'9567

Catalog #: 8897 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8897/5

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AZ'9567 | CAS No. 3056570-19-2 | Other Transferase Inhibitors
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Description: Potent MAT2a (methionine adenosyltransferase 2a) inhibitor

Chemical Name: 3-Cyclopropyl-4-[4-(difluoromethoxy)phenyl]-1,4-dihydro-6-(2-methyl-2H-indazol-5-yl)-5H-pyrazolo[4,3-b]pyridin-5-one

Purity: ≥98%

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Biological Activity

AZ''9567 is a potent MAT2a (methionine adenosyltransferase 2a) inhibitor (IC50 = 1.3 nM). AZ'9567 shows strong antiproliferative effect on methylthioadenosine phosphorylase (MTAP) null lymphoma, lung, and pancreatic cancer cell lines and in vivo in MTAP KO HCT116 xenograft mouse model (20 mg/kg twice a day). AZ''9567 is orally bioavailable.

Technical Data

M.Wt:
447.45
Formula:
C24H19F2N5O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
3056570-19-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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