Modulator of unfolded protein response (UPR). Protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER calcium retention. Improves liver ER function, glucose homeostasis and glucose-stimulated insulin secretion in mouse obesity models. Orally bioavailable.
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Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.
Fu et al.