B2

Catalog # Availability Size / Price Qty
2855/10
2855/50
Neuronal Metabolism Peptides and Compounds Small Molecule
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Description: Promotes inclusion formation in Huntington's and Parkinson's diseases
Alternative Names: CPNQ

Chemical Name: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

Purity: ≥98%

Product Details
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Biological Activity

Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

Technical Data

M.Wt:
396.83
Formula:
C20H17ClN4O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
115687-05-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parksinson's diseases.
    Bodner et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:4246

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