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B2

Catalog #: 2855 Datasheet / COA / SDS

Discontinued Product

2855 has been discontinued.
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B2 | CAS No. 115687-05-3 | Neuronal Metabolism Peptides and Compounds
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Description: Promotes inclusion formation in Huntington's and Parkinson's diseases
Alternative Names: CPNQ

Chemical Name: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

Purity: ≥98%

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Biological Activity

B2 is a promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

Technical Data

M.Wt:
396.83
Formula:
C20H17ClN4O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
115687-05-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parksinson's diseases.
    Bodner et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:4246

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