pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ
. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ
. Acts as a PPARγ
agonist in an ECV304 cell line. Also produces PPARγ
-independent apoptosis of tumor cells via several mechanisms. Active in vivo
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Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line.
Bishop-Bailey et al.
Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO.
Fehlberg et al.
Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation.
Cuzzocrea et al.
A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation.
Wright et al.