Chemical Name: 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane
Biological ActivityPPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Also produces PPARγ-independent apoptosis of tumor cells via several mechanisms. Active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line.
Bishop-Bailey et al.
Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation.
Cuzzocrea et al.
Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO.
Fehlberg et al.
A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation.
Wright et al.
Citations for BADGE
The citations listed below are publications that use Tocris products. Selected citations for BADGE include:
3 Citations: Showing 1 - 3
Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
Authors: Alharris Et al.
The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome.
Authors: Kanabus Et al.
J Inherit Metab Dis 2016;39:415
Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo.
Authors: Hegde Et al.
J Immunol 2015;194:5211
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for BADGE
There are currently no reviews for this product. Be the first to review BADGE and earn rewards!
Have you used BADGE?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image