Catalog Number: 1326
Alternate Names: Bisphenol A diglycidyl ether
Chemical Name: 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane
Biological Activity
PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Also produces PPARγ-independent apoptosis of tumor cells via several mechanisms. Active in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line.
    Bishop-Bailey et al.
    Br.J.Pharmacol., 2000;131:651
  2. Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO.
    Fehlberg et al.
    Br.J.Pharmacol., 2003;139:495
  3. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation.
    Cuzzocrea et al.
    Eur.J.Pharmacol., 2004;483:79
  4. A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation.
    Wright et al.
    J.Biol.Chem., 2000;275:1873
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information