Highly potent, selective inhibitor of vacuolar H+
= 0.6 - 1.5 nM in bovine chromaffin granules). Selective for v-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+
-ATPase (P-ATPase). Thought to inhibit autophagy either by blocking autophagosome-lysosome fusion (in H4IIE cells), or by blocking lysosomal degradation.
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Chemistry and stucture activity relationships of bafilomycin A1, a potent and selective inhibitor of the vacuolar H+-ATPase.
Gagliardi et al.
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
Yamamoto et al.
Cell Struct.Funct., 1998;23:33
Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes.
Fass et al.
The citations listed below are publications that use Tocris products. Selected citations for Bafilomycin A1 include:
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