Bafilomycin A1

  ( 32 citations )    
Product Datasheet
Catalog Number:1334
Chemical Name:(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Product Details
Citations (32)
Biological Activity
Highly potent, selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 - 1.5 nM in bovine chromaffin granules). Selective for v-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+/K+-ATPase (P-ATPase). Thought to inhibit autophagy either by blocking autophagosome-lysosome fusion (in H4IIE cells), or by blocking lysosomal degradation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for Bafilomycin A1 include:

32 Citations: Showing 1 - 10
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  1. Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation.
    Authors: Jacquin Et al.
    Autophagy  2017;13:854
  2. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.
    Authors: Dai Et al.
    Autophagy  2017;13:1435
  3. Down regulated lncRNA MEG3 eliminates mycobacteria in macrophages via autophagy.
    Authors: Pawar Et al.
    Radiat Oncol  2016;6:19416
  4. Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.
    Authors: DeJesus Et al.
    Elife  2016;5
  5. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
    Authors: Holler Et al.
    Mol Neurodegener  2016;11:46
  6. Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.
    Authors: Lin Et al.
    Sci Rep  2015;290:3377
  7. Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.
    Authors: Cao Et al.
    Int J Mol Sci  2015;209:879
  8. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    J Clin Invest  2015;16:5555
  9. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
    Authors: Zhu Et al.
    J Biol Chem  2015;125:1098
  10. Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy.
    Authors: Hsu Et al.
    Autophagy  2015;11:643
  11. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    J Cell Biol  2015;11:1114
  12. Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation.
    Authors: Hennel Et al.
    Mol Biol Cell  2014;9:85
  13. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.
    Authors: Kondratskyi Et al.
    Cell Death Dis  2014;5:e1193
  14. Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
    Authors: Verstegen Et al.
    J Neurosci  2014;34:7266
  15. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
    Authors: Gutierrez Et al.
    J Biol Chem  2014;289:33568
  16. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells.
    Authors: Said Et al.
    J Immunol  2014;193:6135
  17. Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells.
    Authors: Manes and Pober
    J Immunol  2014;193:5809
  18. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
    Authors: Huang Et al.
    Nat Immunol  2014;15:846
  19. Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.
    Authors: McAlpine Et al.
    Autophagy  2013;9:361
  20. Characteristics and requirements of basal autophagy in HEK 293 cells.
    Authors: Musiwaro Et al.
    Autophagy  2013;9:1407
  21. Pulsed electromagnetic fields increased the anti-inflammatory effect of A2A and A3 adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts.
    Authors: Vincenzi Et al.
    PLoS One  2013;8:e65561
  22. Autophagy-mediated turnover of dynamin-related protein 1.
    Authors: Purnell and Fox
    BMC Neurosci  2013;14:86
  23. The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.
    Authors: Robert Et al.
    Autophagy  2012;8:637
  24. Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens.
    Authors: Ladoire Et al.
    Autophagy  2012;8:1175
  25. West Nile virus growth is independent of autophagy activation.
    Authors: Beatman Et al.
    Virology  2012;433:262
  26. Negative regulation of signaling by a soluble form of toll-like receptor 9.
    Authors: Chockalingam Et al.
    Eur J Immunol  2011;41:2176
  27. Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors.
    Authors: Ruthel Et al.
    Toxins (Basel)  2011;3:207
  28. Relieving autophagy and 4EBP1 from rapamycin resistance.
    Authors: Nyfeler Et al.
    Mol Cell Biol  2011;31:2867
  29. Notch post-translationally regulates β-catenin protein in stem and progenitor cells.
    Authors: Kwon Et al.
    Nat Cell Biol  2011;13:1244
  30. Beta1 integrin-dependent engulfment of Yersinia enterocolitica by macrophages is coupled to the activation of autophagy and suppressed by type III protein secretion.
    Authors: Deuretzbacher Et al.
    J Immunol  2009;183:5847
  31. Extrasynaptic release of GABA by retinal dopaminergic neurons.
    Authors: Hirasawa Et al.
    J Neurophysiol  2009;102:146
  32. Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.
    Authors: Ganesan Et al.
    PLoS Genet  2008;4:e1000298
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