Catalog Number: 3661
Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide
Biological Activity
Potent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.
Technical Data
  • M.Wt:
    506.51
  • Formula:
    C27H35N3O2.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    1401463-54-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
    Goto et al.
    J.Med.Chem., 2006;49:847
  2. 1-Benzyl-N-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices.
    Liao et al.
    Eur.J.Pharmacol., 2009;606:84
  3. Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24.
    Fischetti et al.
    Eur.J.Pharmacol., 2009;614:50
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BAN ORL 24 include:

1 Citations: Showing 1 - 1

  1. Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
    Authors: Aatsinki Et al.
    Am J Physiol Cell Physiol 2014;171:2351

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