BAN ORL 24

Name: BAN ORL 24
Brand: Tocris Bioscience
SKU: 3661

Catalog #: 3661
1 Citation Datasheet / COA / SDS

Discontinued Product

3661 has been discontinued.

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BAN ORL 24 | CAS No. 1401463-54-4 | NOP Receptor Antagonists

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Description: Potent and selective NOP antagonist

Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide dihydrochloride

Purity: ≥97%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent and selective NOP receptor antagonist (IC₅₀ values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [³⁵S]-GTPγS binding and Ca²⁺ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.

Technical Data

M.Wt:

506.51

Formula:

C₂₇H₃₅N₃O₂.2HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥97%

Storage:

Store at -20°C

CAS No:

1401463-54-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
Goto et al.
J.Med.Chem., 2006;49:847
1-Benzyl-N-[spiroisobenzofuran-1(³H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices.
Liao et al.
Eur.J.Pharmacol., 2009;606:84
Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24.
Fischetti et al.
Eur.J.Pharmacol., 2009;614:50

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Citation for BAN ORL 24

The citations listed below are publications that use Tocris products. Selected citations for BAN ORL 24 include:

1 Citation: Showing 1 - 1

MetF. induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
Authors: Aatsinki Et al.
Am J Physiol Cell Physiol 2014;171:2351

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