BAN ORL 24

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3661/10
3661/50
BAN ORL 24 | CAS No. 1401463-54-4 | NOP Receptor Antagonists
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Description: Potent and selective NOP antagonist

Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity

Potent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.

Technical Data

M.Wt:
506.51
Formula:
C27H35N3O2.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1401463-54-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for BAN ORL 24

The citations listed below are publications that use Tocris products. Selected citations for BAN ORL 24 include:

1 Citation: Showing 1 - 1

  1. MetF. induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
    Authors: Aatsinki Et al.
    Am J Physiol Cell Physiol  2014;171:2351

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