Discontinued Product

3661 has been discontinued.
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BAN ORL 24 | CAS No. 1401463-54-4 | NOP Receptor Antagonists
1 Image
Description: Potent and selective NOP antagonist

Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide dihydrochloride

Purity: ≥97%

Product Details
Citations (1)

Biological Activity

Potent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for BAN ORL 24

The citations listed below are publications that use Tocris products. Selected citations for BAN ORL 24 include:

1 Citation: Showing 1 - 1

  1. MetF. induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
    Authors: Aatsinki Et al.
    Am J Physiol Cell Physiol  2014;171:2351


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