Potent and selective NOP receptor antagonist (IC50
values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ
- and δ
-receptors respectively). Inhibits nociceptin-induced stimulation of [35
S binding and Ca2+
mobilization in CHO cells in vitro
and antagonizes NOP agonist-induced reduction in locomotor activity in vivo
. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
Goto et al.
1-Benzyl-N-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices.
Liao et al.
Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24.
Fischetti et al.
The citations listed below are publications that use Tocris products. Selected citations for BAN ORL 24 include:
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