BAN ORL 24
Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide dihydrochloride
Biological ActivityPotent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.
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Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
Goto et al.
1-Benzyl-N-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices.
Liao et al.
Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24.
Fischetti et al.
Citation for BAN ORL 24
The citations listed below are publications that use Tocris products. Selected citations for BAN ORL 24 include:
1 Citation: Showing 1 - 1
MetF. induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
Authors: Aatsinki Et al.
Am J Physiol Cell Physiol 2014;171:2351
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