Batimastat

  ( 23 citations )    
Product Datasheet
Catalog Number:2961
Alternate Names:BB-94
Chemical Name:(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
Product Details
Citations (23)
Reviews
Biological Activity
Potent, broad spectrum MMP inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.
Technical Data
  • M.Wt:
    477.64
  • Formula:
    C23H31N3O4S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    130370-60-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Batimastat include:

23 Citations: Showing 1 - 10
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  1. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.
    Authors: Sanz
    Sci Rep  2017;7(1):7961
  2. Involvement of PI3K and MMP1 in PDGF-induced Migration of Human Adipose-derived Stem Cells.
    Authors: Lim Et al.
    Dev Reprod  2017;21:167
  3. M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop.
    Authors: Carroll Et al.
    Oncotarget  2016;7:86608
  4. Epithelial innate immune response to Acinetobacter baumannii challenge.
    Authors: Feng Et al.
    Br J Cancer  2014;82:4458
  5. EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1.
    Authors: Ji Et al.
    Nat Commun  2014;5:3516
  6. Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.
    Authors: Esteso Et al.
    J Immunol  2014;193:1344
  7. MMP regulation of corneal keratocyte motility and mechanics in 3-D collagen matrices.
    Authors: Zhou and Petroll
    Exp Eye Res  2014;121:147
  8. Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells.
    Authors: Woods and Padmanabhan
    J Biol Chem  2013;288:30114
  9. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman Et al.
    Korean J Physiol Pharmacol  2013;20:369
  10. TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR.
    Authors: Yoo Et al.
    Infect Immun  2013;13:90
  11. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
    Authors: Mezil Et al.
    PLoS One  2012;7:e43409
  12. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.
    Authors: Yin Et al.
    Am J Physiol Endocrinol Metab  2012;303:E55
  13. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
    Authors: Yurtsever Et al.
    Development  2012;287:42138
  14. The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.
    Authors: Jijon Et al.
    Mediators Inflamm  2012;2012:207398
  15. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
    Authors: Prendergast Et al.
    BMC Gastroenterol  2012;139:1141
  16. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.
    Authors: Kalous Et al.
    J Neurochem  2012;122:523
  17. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition.
    Authors: Walsh and Damjanovski
    BMC Neurosci  2011;9:10
  18. Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion.
    Authors: Sims Et al.
    PLoS One  2011;6:e18848
  19. Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus.
    Authors: Dang Et al.
    J Biol Chem  2011;286:17704
  20. Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells.
    Authors: Kim Et al.
    J Biol Chem  2011;15:211
  21. Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice.
    Authors: Park Et al.
    Korean J Physiol Pharmacol  2011;15:115
  22. Notch post-translationally regulates β-catenin protein in stem and progenitor cells.
    Authors: Kwon Et al.
    Nat Cell Biol  2011;13:1244
  23. Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.
    Authors: Hamasaki Et al.
    Cell Commun Signal  2011;105:824
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