Chemical Name: (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
Biological ActivityBatimastat is a potent, broad spectrum MMP inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.
Wang et al.
Cancer Res., 1994;54:4726
Molecular insights into cancer invasion: strategies for prevention and intervention.
Kohn and Liotta
Cancer Res., 1995;55:1856
A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.
Davies et al.
Cancer Res., 1993;53:2087
Citations for Batimastat
The citations listed below are publications that use Tocris products. Selected citations for Batimastat include:
29 Citations: Showing 1 - 10
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.
Authors: Orth-He Et al.
Cell Rep 2023;42:111965
Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus.
Authors: Baggen Et al.
Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.
Sci Rep 2017;7(1):7961
Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Authors: Pitt Et al.
Mol Biol Cell 2017;28:2623
Involvement of PI3K and MMP1 in PDGF-induced Migration of Human Adipose-derived Stem Cells.
Authors: Lim Et al.
Dev Reprod 2017;21:167
Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors.
Authors: Ren Et al.
Methods Mol Biol 2017;1626:79
M2 macrophages induce ovarian cancer cell proliferation via a he. binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop.
Authors: Carroll Et al.
A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding.
Authors: Wojtalewicz Et al.
PLoS One 2014;9:e90461
Epithelial innate immune response to Acinetobacter baumannii challenge.
Authors: Feng Et al.
Br J Cancer 2014;82:4458
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1.
Authors: Ji Et al.
Nat Commun 2014;5:3516
Metalloprotease dependent release of placenta derived fractalkine.
Authors: Siwetz Et al.
Mediators Inflamm 2014;2014:839290
Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.
Authors: Esteso Et al.
J Immunol 2014;193:1344
MMP regulation of corneal keratocyte motility and mechanics in 3-D collagen matrices.
Authors: Zhou and Petroll
Exp Eye Res 2014;121:147
Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells.
Authors: Woods and Padmanabhan
J Biol Chem 2013;288:30114
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Authors: Brafman Et al.
Korean J Physiol Pharmacol 2013;20:369
TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR.
Authors: Yoo Et al.
Infect Immun 2013;13:90
Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
Authors: Mezil Et al.
PLoS One 2012;7:e43409
Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.
Authors: Yin Et al.
Am J Physiol Endocrinol Metab 2012;303:E55
Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
Authors: Yurtsever Et al.
The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.
Authors: Jijon Et al.
Mediators Inflamm 2012;2012:207398
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
Authors: Prendergast Et al.
BMC Gastroenterol 2012;139:1141
Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.
Authors: Kalous Et al.
J Neurochem 2012;122:523
IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition.
Authors: Walsh and Damjanovski
BMC Neurosci 2011;9:10
Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion.
Authors: Sims Et al.
PLoS One 2011;6:e18848
Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus.
Authors: Dang Et al.
J Biol Chem 2011;286:17704
Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells.
Authors: Kim Et al.
J Biol Chem 2011;15:211
Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice.
Authors: Park Et al.
Korean J Physiol Pharmacol 2011;15:115
Notch post-translationally regulates β-catenin protein in stem and progenitor cells.
Authors: Kwon Et al.
Nat Cell Biol 2011;13:1244
Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.
Authors: Hamasaki Et al.
Cell Commun Signal 2011;105:824
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