Catalog Number: 2961
Alternate Names: BB-94
Chemical Name: (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
Biological Activity
Potent, broad spectrum MMP inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.
    Davies et al.
    Cancer Res., 1993;53:2087
  2. Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.
    Wang et al.
    Cancer Res., 1994;54:4726
  3. Molecular insights into cancer invasion: strategies for prevention and intervention.
    Kohn and Liotta
    Cancer Res., 1995;55:1856

The citations listed below are publications that use Tocris products. Selected citations for Batimastat include:

19 Citations: Showing 1 - 10
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  1. Epithelial innate immune response to Acinetobacter baumannii challenge.
    Authors: Feng Et al.
    Br J Cancer 2014;82:4458
  2. EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1.
    Authors: Ji Et al.
    Nat Commun 2014;5:3516
  3. Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.
    Authors: Esteso Et al.
    J Immunol 2014;193:1344
  4. Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells.
    Authors: Woods and Padmanabhan
    J Biol Chem 2013;288:30114
  5. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman Et al.
    Korean J Physiol Pharmacol 2013;20:369
  6. TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR.
    Authors: Yoo Et al.
    Infect Immun 2013;13:90
  7. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
    Authors: Mezil Et al.
    PLoS One 2012;7:e43409
  8. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.
    Authors: Yin Et al.
    Am J Physiol Endocrinol Metab 2012;303:E55
  9. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
    Authors: Yurtsever Et al.
    Development 2012;287:42138
  10. The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.
    Authors: Jijon Et al.
    Mediators Inflamm 2012;2012:207398
  11. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
    Authors: Prendergast Et al.
    BMC Gastroenterol 2012;139:1141
  12. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.
    Authors: Kalous Et al.
    J Neurochem 2012;122:523
  13. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition.
    Authors: Walsh and Damjanovski
    BMC Neurosci 2011;9:10
  14. Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion.
    Authors: Sims Et al.
    PLoS One 2011;6:e18848
  15. Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus.
    Authors: Dang Et al.
    J Biol Chem 2011;286:17704
  16. Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells.
    Authors: Kim Et al.
    J Biol Chem 2011;15:211
  17. Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice.
    Authors: Park Et al.
    Korean J Physiol Pharmacol 2011;15:115
  18. Notch post-translationally regulates β-catenin protein in stem and progenitor cells.
    Authors: Kwon Et al.
    Nat Cell Biol 2011;13:1244
  19. Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.
    Authors: Hamasaki Et al.
    Cell Commun Signal 2011;105:824
Expand to show all 19 Citations

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