Biological ActivityBay 55-9837 is a selective VPAC2 receptor agonist (EC50 values are 0.4, 100 and >1000 nM for VPAC2, VPAC1 and PAC1, respectively in a cAMP accumulation assay; IC50 values are 60, 8700 and >10000 nM for VPAC2, VPAC1 and PAC1, respectively in a competition binding assay). Stimulates glucose-dependent insulin secretion in isolated human pancreatic islets. Reduces HIV-1 viral replication and shows cooperative effects when given in conjunction with VPAC1 agonists.
(Modifications: Tyr-31 = C-terminal amide)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Macrophage resistance to HIV-1 infection is enhanced by the neuropeptides VIP and PACAP.
Temerozo et al.
PLoS ONE, 2013;8:67701
A potent and highly selective VPAC2 agonist enhances glucose-induced Ins release and glucose disposal: a potential therapy for type 2 diabetes.
Tsutsumi et al.
Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal.
Clairmont et al.
Engineering novel VPAC2-selective agonists with improved stability and glucose-lowering activity in vivo.
Pan et al.
Citations for Bay 55-9837
The citations listed below are publications that use Tocris products. Selected citations for Bay 55-9837 include:
4 Citations: Showing 1 - 4
Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
Authors: Hamnett Et al.
Nat Commun 2019;10:542
A subnanomolar concentration of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine
Authors: Valeria Et al.
Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Authors: Toda and Huganir
Purinergic Signal 2015;112:6712
Chronic stimulation of the hypothalamic vasoactive intestinal peptide receptor lengthens circadian period in mice and hamsters.
Authors: Pantazopoulos Et al.
Am J Physiol Regul Integr Comp Physiol 2010;299:R379
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