Catalog Number: 0511
Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide
Biological Activity
Potent and selective σ-ligand (Ki against [3H]-(+)-3-PPP = 0.34 nM).
Technical Data
  • M.Wt:
    463.08
  • Formula:
    C15H22Cl2N2.2HBr
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Store at -20°C
  • CAS No:
    138356-09-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor.
    De Costa et al.
    J.Med.Chem., 1992;35:38
  2. Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices.
    Monnet et al.
    Br.J.Pharmacol., 1996;119:65
  3. Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition.
    Whittemore et al.
    J.Pharmacol.Exp.Ther., 1997;282:326
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BD 1008 dihydrobromide include:

2 Citations: Showing 1 - 2
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  1. Stimulants as specific inducers of dopamine-independentσ agonist self-administration in rats.
    Authors: Hiranita Et al.
    Neurochem Int 2013;347:42633
  2. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
    Authors: Hiranita Et al.
    J Pharmacol Exp Ther 2011;339:662

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