Catalog Number: 0926
Alternate Names: β-FNA
Chemical Name: (E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride
Biological Activity
Selective μ opioid receptor antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Minnesota
Background References
  1. μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice.
    Jiang et al.
    J.Pharmacol.Exp.Ther., 1990;252:1006
  2. The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltrexone.
    Takemorei et al.
    Eur.J.Pharmacol., 1981;70:445

The citations listed below are publications that use Tocris products. Selected citations for β-Funaltrexamine hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Neuropsychopharmacology 2015;10:e0145556
  2. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Circulation 2013;38:1296
  3. Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats.
    Authors: Tzeng Et al.
    Evid Based Complement Alternat Med 2011;2011:150752
  4. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
    Authors: Largent-Milnes Et al.
    Br J Pharmacol 2010;161:986
  5. Differential responses to morphine-induced analgesia in the tail-flick test.
    Authors: Cecchi Et al.
    Behav Brain Res 2008;194:146

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