Catalog Number: 2503
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Biological Activity
Methiodide form of classical GABAA receptor antagonist (+)-bicuculline (Cat. No. 0130). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Studies on the neuropharmacological activity of bicuculline and related compounds.
    Olsen et al.
    Brain Res., 1976;102:283
  2. Recent advances in the pharmacology of quaternary salts of bicuculline.
    Seutin and Johnson
    TiPS, 1999;20:268
  3. Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.
    Chan et al.
    Diabetes, 2006;55:1080
  4. Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex.
    Kurt et al.
    Hear.Res., 2006;212:224

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methiodide include:

Showing Results 1 - 10 of 25

  1. Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity.
    Authors: Cichon and Gan
  2. Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress.
    Authors: Ootsuka and Mohammed
    J Virol
  3. In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse.
    Authors: Fehérvári Et al.
    PLoS One
  4. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Neurosci
  5. Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth.
    Authors: Pedroni Et al.
    Front Cell Neurosci
  6. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    J Neurophysiol
  7. Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons.
    Authors: Zhang Et al.
    PLoS Pathog
  8. GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
    Authors: Tashiro Et al.
    Proc Natl Acad Sci U S A
  9. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.
    Authors: Kempf Et al.
    PLoS Biol
  10. Role of inhibition in respiratory pattern generation.
    Authors: Janczewski Et al.
    J Neurosci
  11. The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
    Authors: Wagner Et al.
    Physiol Rep
  12. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol
  13. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
    Authors: He Et al.
  14. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One
  15. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
    Authors: He Et al.
  16. Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
    Authors: Gallo and Iadecola
    J Neurosci
  17. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Pharmacol Res Perspect
  18. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
  19. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    Authors: Jackson Et al.
    PLoS One
  20. Activation of NR2A receptors induces ischemic tolerance through CREB signaling.
    Authors: Terasaki Et al.
    J Cereb Blood Flow Metab
  21. KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.
    Authors: Bortone and Polleux
  22. Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.
    Authors: Prat Et al.
  23. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    PLoS One
  24. Borna disease virus infection impairs synaptic plasticity.
    Authors: Volmer Et al.
    J Biol Chem
  25. Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.
    Authors: Young Et al.
    Neurobiol Dis
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