(-)-Bicuculline methiodide

  ( 34 citations )    
Product Datasheet
Catalog Number:2503
Chemical Name:[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Product Details
Citations (34)
Supplemental Products
Reviews
Biological Activity
Methiodide form of classical GABAA receptor antagonist (+)-bicuculline. More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.

Methobromide Salt and Methochloride Salt also available.

Technical Data
  • M.Wt:
    509.3
  • Formula:
    C21H20INO6
  • Solubility:
    Soluble to 20 mM in water and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    40709-69-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methiodide include:

34 Citations: Showing 1 - 10
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  1. HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
    Authors: Ahsan Raza
    Nat Commun  2017;8(1):189
  2. Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking.
    Authors: Zhang Et al.
    J Biol Chem  2016;291:18856
  3. Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity.
    Authors: Cichon and Gan
    Nature  2015;520:180
  4. Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress.
    Authors: Ootsuka and Mohammed
    J Virol  2015;3
  5. Activity-dependent differences in function between proximal and distal Schaffer collaterals.
    Authors: Owen and Grover
    J Neurophysiol  2015;113:3646
  6. In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse.
    Authors: Fehérvári Et al.
    PLoS One  2015;10:e0133853
  7. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Neurosci  2015;10:e0124986
  8. Dopamine preferentially inhibits NMDA receptor-mediated EPSCs by acting on presynaptic D1 receptors in nucleus accumbens during postnatal development.
    Authors: Zhang Et al.
    PLoS One  2014;9:e86970
  9. Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth.
    Authors: Pedroni Et al.
    Front Cell Neurosci  2014;8:44
  10. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    J Neurophysiol  2014;77:379
  11. Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons.
    Authors: Zhang Et al.
    PLoS Pathog  2014;289:31200
  12. GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
    Authors: Tashiro Et al.
    Proc Natl Acad Sci U S A  2014;259:53
  13. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.
    Authors: Kempf Et al.
    PLoS Biol  2014;12:e1001763
  14. Role of inhibition in respiratory pattern generation.
    Authors: Janczewski Et al.
    J Neurosci  2013;33:5454
  15. The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
    Authors: Wagner Et al.
    Physiol Rep  2013;238:29
  16. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol  2013;109:2528
  17. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
    Authors: He Et al.
    Neuroscience  2013;109:1535
  18. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One  2012;7:e36397
  19. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
    Authors: He Et al.
    Neuropsychopharmacology  2012;37:1338
  20. Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents.
    Authors: Zhu Et al.
    J Neurophysiol  2012;108:2581
  21. Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
    Authors: Kim Et al.
    J Neurophysiol  2012;108:1965
  22. D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.
    Authors: Kohnomi Et al.
    J Neurophysiol  2012;107:692
  23. Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
    Authors: Gallo and Iadecola
    J Neurosci  2011;31:6947
  24. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Pharmacol Res Perspect  2011;31:3077
  25. Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.
    Authors: Pennock and Hentges
    J Neurosci  2011;31:281
  26. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  27. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    Authors: Jackson Et al.
    PLoS One  2010;5:e11962
  28. Activation of NR2A receptors induces ischemic tolerance through CREB signaling.
    Authors: Terasaki Et al.
    J Cereb Blood Flow Metab  2010;30:1441
  29. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  30. KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.
    Authors: Bortone and Polleux
    Neuron  2009;62:53
  31. Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.
    Authors: Prat Et al.
    Neuroscience  2009;5:e1000425
  32. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    PLoS One  2008;105:9093
  33. Borna disease virus infection impairs synaptic plasticity.
    Authors: Volmer Et al.
    J Biol Chem  2007;81:8833
  34. Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.
    Authors: Young Et al.
    Neurobiol Dis  2007;26:78
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