Catalog Number: 2503
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Biological Activity
Methiodide form of classical GABAA receptor antagonist (+)-bicuculline (Cat. No. 0130). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
Technical Data
  • M.Wt:
    509.3
  • Formula:
    C21H20INO6
  • Solubility:
    Soluble to 20 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    40709-69-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Studies on the neuropharmacological activity of bicuculline and related compounds.
    Olsen et al.
    Brain Res., 1976;102:283
  2. Recent advances in the pharmacology of quaternary salts of bicuculline.
    Seutin and Johnson
    TiPS, 1999;20:268
  3. Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.
    Chan et al.
    Diabetes, 2006;55:1080
  4. Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex.
    Kurt et al.
    Hear.Res., 2006;212:224
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methiodide include:

25 Citations: Showing 1 - 10
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  1. Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity.
    Authors: Cichon and Gan
    Nature 2015;520:180
  2. Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress.
    Authors: Ootsuka and Mohammed
    J Virol 2015;3
  3. In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse.
    Authors: Fehérvári Et al.
    PLoS One 2015;10:e0133853
  4. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Neurosci 2015;10:e0124986
  5. Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth.
    Authors: Pedroni Et al.
    Front Cell Neurosci 2014;8:44
  6. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    J Neurophysiol 2014;77:379
  7. Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons.
    Authors: Zhang Et al.
    PLoS Pathog 2014;289:31200
  8. GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
    Authors: Tashiro Et al.
    Proc Natl Acad Sci U S A 2014;259:53
  9. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.
    Authors: Kempf Et al.
    PLoS Biol 2014;12:e1001763
  10. Role of inhibition in respiratory pattern generation.
    Authors: Janczewski Et al.
    J Neurosci 2013;33:5454
  11. The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
    Authors: Wagner Et al.
    Physiol Rep 2013;238:29
  12. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol 2013;109:2528
  13. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
    Authors: He Et al.
    Neuroscience 2013;109:1535
  14. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One 2012;7:e36397
  15. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
    Authors: He Et al.
    Neuropsychopharmacology 2012;37:1338
  16. Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
    Authors: Gallo and Iadecola
    J Neurosci 2011;31:6947
  17. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Pharmacol Res Perspect 2011;31:3077
  18. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology 2011;152:3842
  19. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    Authors: Jackson Et al.
    PLoS One 2010;5:e11962
  20. Activation of NR2A receptors induces ischemic tolerance through CREB signaling.
    Authors: Terasaki Et al.
    J Cereb Blood Flow Metab 2010;30:1441
  21. KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.
    Authors: Bortone and Polleux
    Neuron 2009;62:53
  22. Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.
    Authors: Prat Et al.
    Neuroscience 2009;5:e1000425
  23. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    PLoS One 2008;105:9093
  24. Borna disease virus infection impairs synaptic plasticity.
    Authors: Volmer Et al.
    J Biol Chem 2007;81:8833
  25. Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.
    Authors: Young Et al.
    Neurobiol Dis 2007;26:78
Expand to show all 25 Citations

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