Methiodide form of classical GABAA
receptor antagonist (+)-bicuculline
(Cat. No. 0130). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Studies on the neuropharmacological activity of bicuculline and related compounds.
Olsen et al.
Brain Res., 1976;102:283
Recent advances in the pharmacology of quaternary salts of bicuculline.
Seutin and Johnson
Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.
Chan et al.
Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex.
Kurt et al.
The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methiodide include:
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