Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Biological ActivityMethiodide form of classical GABAA receptor antagonist (+)-bicuculline. More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Studies on the neuropharmacological activity of bicuculline and related compounds.
Olsen et al.
Brain Res., 1976;102:283
Recent advances in the pharmacology of quaternary salts of bicuculline.
Seutin and Johnson
Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.
Chan et al.
Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex.
Kurt et al.
Citations for (-)-Bicuculline methiodide
The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methiodide include:
51 Citations: Showing 1 - 10
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Authors: Chiu Et al.
Cell Rep 2019;28:332
KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission.
Authors: Ye Et al.
Wilm's tumor 1 promotes memory flexibility.
Authors: Mariottini Et al.
Nat Commun 2019;10:3756
Salicylate-Induced Suppression of Electrically Driven Activity in Brain Slices from the Auditory Cortex of Aging Mice.
Authors: Namikawa Et al.
Front Aging Neurosci 2018;9:395
Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
Authors: Wang Et al.
Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR.
Authors: Hangen Et al.
Cell Rep 2018;24:1001
(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins.
Authors: Francois Et al.
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
Authors: Ahsan Raza
Nat Commun 2017;8(1):189
Amygdalar endothelin-1 regulates pyramidal neuron excitability and affects anxiety.
Authors: Chen Et al.
Sci Rep 2017;7:2316
Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity.
Authors: Fox and Hentges
J Neurosci 2017;37:8667
Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis.
Authors: Zhang and Lu
J Biol Chem 2017;292:15481
A versatile optical tool for studying synaptic GABAA receptor trafficking.
Authors: Lorenz-Guertin Et al.
J Cell Sci 2017;130:3933
Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking.
Authors: Zhang Et al.
J Biol Chem 2016;291:18856
Diminished KCC2 confounds synapse specificity of LTP during senescence.
Authors: Ferando Et al.
Nat Neurosci 2016;19:1197
Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms.
Authors: Weng Et al.
Front Cell Neurosci 2016;10:247
Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity.
Authors: Cichon and Gan
Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress.
Authors: Ootsuka and Mohammed
J Virol 2015;3
Activity-dependent differences in function between proximal and distal Schaffer collaterals.
Authors: Owen and Grover
J Neurophysiol 2015;113:3646
In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse.
Authors: Fehérvári Et al.
PLoS One 2015;10:e0133853
DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
Authors: Rioult-Pedotti Et al.
J Neurosci 2015;10:e0124986
DA preferentially inhibits NMDA receptor-mediated EPSCs by acting on presynaptic D1 receptors in nucleus accumbens during postnatal development.
Authors: Zhang Et al.
PLoS One 2014;9:e86970
Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth.
Authors: Pedroni Et al.
Front Cell Neurosci 2014;8:44
Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
Authors: He and Bausch
J Neurophysiol 2014;77:379
Glycine induces bidirectional modifications in N-MthD.-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons.
Authors: Zhang Et al.
PLoS Pathog 2014;289:31200
GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
Authors: Tashiro Et al.
Proc Natl Acad Sci U S A 2014;259:53
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.
Authors: Kempf Et al.
PLoS Biol 2014;12:e1001763
Role of inhibition in respiratory pattern generation.
Authors: Janczewski Et al.
J Neurosci 2013;33:5454
The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
Authors: Wagner Et al.
Physiol Rep 2013;238:29
Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
Authors: Benton Et al.
J Neurophysiol 2013;109:2528
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition.
Authors: He Et al.
Striatal DA transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
Authors: Platt Et al.
PLoS One 2012;7:e36397
Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
Authors: He Et al.
Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice.
Authors: Song Et al.
Cell Transplant 2012;22:2001
Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents.
Authors: Zhu Et al.
J Neurophysiol 2012;108:2581
Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
Authors: Kim Et al.
J Neurophysiol 2012;108:1965
D(2)-like DA receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.
Authors: Kohnomi Et al.
J Neurophysiol 2012;107:692
Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
Authors: Gallo and Iadecola
J Neurosci 2011;31:6947
Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
Authors: Lussier Et al.
Pharmacol Res Perspect 2011;31:3077
Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.
Authors: Pennock and Hentges
J Neurosci 2011;31:281
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Authors: Zemkova Et al.
Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
Authors: Jackson Et al.
PLoS One 2010;5:e11962
Activation of NR2A receptors induces ischemic tolerance through CREB signaling.
Authors: Terasaki Et al.
J Cereb Blood Flow Metab 2010;30:1441
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.
Authors: Bortone and Polleux
Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.
Authors: Prat Et al.
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
Authors: Wayman Et al.
PLoS One 2008;105:9093
Borna disease virus infection impairs synaptic plasticity.
Authors: Volmer Et al.
J Biol Chem 2007;81:8833
Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.
Authors: Young Et al.
Neurobiol Dis 2007;26:78
HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.
Authors: Chan Et al.
J Neurosci 2004;24:9921
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Bicuculline methiodide (Bic) was used to test GABA-A receptors pharmacological properties after expression in pre-transfected HEK cells. 100 microM of Bic fullu suppressed chloride current generated by application of 50 microM GABA at outside-out membrane patch. Figure: black trace - application of GABA, grey trace - application of GABA+Bic.