Somatostatin receptor ligand (Ki
values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5
receptors respectively). Behaves as an antagonist on SRIF14-induced [35
S binding at sst3
values are 6.33 and 5.84 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor.
Wilkinson et al.
Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding.
Siehler and Hoyer
Naunyn Schmiedebergs Arch.Pharmacol., 1999;360:500
Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
Patel and Srikant
Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
Raynor et al.