Catalog Number: 1844
Biological Activity
Somatostatin receptor ligand (Ki values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [35S]-GTPγS binding at sst3 and sst5 receptors (PKB values are 6.33 and 5.84 respectively).
Technical Data
  • M.Wt:
    1232.49
  • Formula:
    C71H81N11O9
  • Sequence:
    FFYWKVFX

    (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = D-Nal & C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 20% acetonitrile / water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    150155-61-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor.
    Wilkinson et al.
    Br.J.Pharmacol., 1996;118:445
  2. Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding.
    Siehler and Hoyer
    Naunyn Schmiedebergs Arch.Pharmacol., 1999;360:500
  3. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
    Patel and Srikant
    Endocrinology, 1994;135:2814
  4. Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
    Raynor et al.
    Mol.Pharmacol., 1993;43:838

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