Chemical Name: (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate
Biological ActivityA selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Heible et al.
Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency.
Kaumann and Lemoine
Naunyn Schmiedebergs Arch.Pharmacol., 1985;331:27
Studies on the receptor profile of bisop.
Klockow et al.
Citations for (±)-Bisoprolol hemifumarate
The citations listed below are publications that use Tocris products. Selected citations for (±)-Bisoprolol hemifumarate include:
3 Citations: Showing 1 - 3
Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
Authors: Littmann Et al.
PLoS One 2015;355:183
Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
Authors: Baker Et al.
FASEB J 2011;25:4486
Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats.
Authors: Kam Et al.
Br J Pharmacol 2005;144:972
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