(±)-Bisoprolol hemifumarate
Discontinued Product
Chemical Name: (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate
Purity: ≥98%
Biological Activity
A selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Heible et al.
J.Med.Chem., 1995;38:3415 -
Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency.
Kaumann and Lemoine
Naunyn Schmiedebergs Arch.Pharmacol., 1985;331:27 -
Studies on the receptor profile of bisop.
Klockow et al.
Arzneimittelforschung, 1986;36:197
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Citations for (±)-Bisoprolol hemifumarate
The citations listed below are publications that use Tocris products. Selected citations for (±)-Bisoprolol hemifumarate include:
3 Citations: Showing 1 - 3
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Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
Authors: Littmann Et al.
PLoS One 2015;355:183
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Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
Authors: Baker Et al.
FASEB J 2011;25:4486
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Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats.
Authors: Kam Et al.
Br J Pharmacol 2005;144:972
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