Catalog Number: 0914
Chemical Name: (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate
Biological Activity
A selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.
Technical Data
  • M.Wt:
    383.48
  • Formula:
    C18H31NO4.½C4H4O4
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    104344-23-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency.
    Kaumann and Lemoine
    Naunyn Schmiedebergs Arch.Pharmacol., 1985;331:27
  2. Studies on the receptor profile of bisoprolol.
    Klockow et al.
    Arzneimittelforschung, 1986;36:197
  3. α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
    Heible et al.
    J.Med.Chem., 1995;38:3415
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (±)-Bisoprolol hemifumarate include:

2 Citations: Showing 1 - 2
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  1. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
    Authors: Littmann Et al.
    PLoS One 2015;355:183
  2. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J 2011;25:4486

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