BMS 182874 hydrochloride
Discontinued Product
Chemical Name: 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide hydrochloride
Purity: ≥98%
Biological Activity
BMS 182874 hydrochloride is a potent, selective and competitive non-peptide endothelin ETA receptor antagonist (Ki = 48 nM). Displays > 1000-fold selectivity over ETB receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo. Inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
Khan et al.
Br.J.Pharmacol., 2006;147:607 -
The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoazolyl)-1-naphthalenesulfonamide.
Stein et al.
J.Med.Chem., 1994;37:329 -
BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist.
Webb et al.
J.Pharmacol.Exp.Ther., 1995;272:1124
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Citations for BMS 182874 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BMS 182874 hydrochloride include:
2 Citations: Showing 1 - 2
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Endothelial cells enhance the migration of bovine meniscus cells.
Authors: Yuan Et al.
Arthritis Rheumatol 2015;67:182
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Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
Authors: Khan Et al.
Br J Pharmacol 2006;147:607
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