BMS 182874 hydrochloride

Catalog # Availability Size / Price Qty
1441/10
1441/50
BMS 182874 hydrochloride | CAS No. 1215703-04-0 | Endothelin ETA Receptor Antagonists
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Description: Highly selective, orally active non-peptide ETA antagonist

Chemical Name: 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide hydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

BMS 182874 hydrochloride is a potent, selective and competitive non-peptide endothelin ETA receptor antagonist (Ki = 48 nM). Displays > 1000-fold selectivity over ETB receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo. Inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro.

Technical Data

M.Wt:
381.88
Formula:
C17H19N3O3S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1215703-04-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Bristol-Myers Squibb Company, subject to U.S. Patent No. 5,378,715 and other US and foreign patents

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Citations for BMS 182874 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BMS 182874 hydrochloride include:

2 Citations: Showing 1 - 2

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