BMS 986094
Chemical Name: Neopentyl [[[(2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl]methoxy](naphthalen-1-yloxy)phosphoryl]-L-alaninate
Purity: ≥98%
Biological Activity
Potent hepatitis C virus (HCV) replication inhibitor (EC50 = 35 nM). Is rapidly metabolized in primary human hepatocytes to 2'-C-methyl guanosine triphosphate, an inhibitor of HCV RNA-dependent RNA polymerase NS5b. Displays 10-fold reduction in potency in S282T mutant-expressing versus wild-type replicons. Exhibits synergy with Ribavirin (Cat. No. 4501). Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
Vernachio et al.
Antimicrob.Agents Chemother., 2011;55:1843 -
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
McGuigan et al.
Bioorg.Med.Chem.Lett., 2010;20:4850
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for BMS 986094
There are currently no reviews for this product. Be the first to review BMS 986094 and earn rewards!
Have you used BMS 986094?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
