BNIP3 Antibody (S09-1G8)

Name: BNIP3 Antibody (S09-1G8)
Brand: Novus Biologicals
SKU: NBP3-19550
Price: 559 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-19550

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S09-1G8 expressed in HEK293

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Product Specifications

Immunogen

A synthetic peptide of human BNIP3 (Uniprot # Q12983)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BNIP3 Antibody (S09-1G8)

Western Blot: BNIP3 Antibody (S09-1G8) [NBP3-19550]

Western Blot: BNIP3 Antibody (S09-1G8) [NBP3-19550] - Western blot detection of BNIP3 in Rat Brain lysates using NBP3-19550 (1:500 diluted). Predicted band size: 28kDa. Observed band size: 28kDa.

Immunocytochemistry/Immunofluorescence: BNIP3 Antibody (S09-1G8) [NBP3-19550] -

Immunocytochemistry/Immunofluorescence: BNIP3 Antibody (S09-1G8) [NBP3-19550] - Immunofluorescence of BNIP3 (green) in Hela cells using NBP3-19550 at dilution 1/50, and DAPI (blue)

Applications for BNIP3 Antibody (S09-1G8)

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

1/50

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BNIP3

BCL2/adenovirus E1B 19kD protein-interacting protein 3 (BNIP3) is a mitochondrial protein critical for apoptotic events in response to adenovirus infection. It has been implicated in causing a necrotic-like cell death pattern in cells, induced by CD47. This effect has been seen in many cancer cells, and its mis-regulation causes tumor cells to be impervious to normal autophagic events. The tumor suppressor p53 represses the expression of BNIP3, often as a consequence of hypoxic micro-environments as seen in tumors. When BNIP3 is correctly expressed and activated, it translocates to the mitochondria and instigates apoptosis.

Long Name

BCL2/Adenovirus E1B 19 Kda Protein-Interacting Protein 3-Like

Alternate Names

Nip3

Gene Symbol

BNIP3

Additional BNIP3 Products

Product Documents for BNIP3 Antibody (S09-1G8)

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Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for BNIP3 Antibody (S09-1G8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Autophagy

Bcl-2 Proteins and Regulators

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