Catalog Number: 4706
Chemical Name: (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
Biological Activity
Antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC50 = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells.
Technical Data
  • M.Wt:
    489.64
  • Formula:
    C28H43NO6
  • Solubility:
    Soluble to 2 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    7184-60-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.
    Wakabayashi et al.
    J.Antibiot.(Tokyo)., 1997;50:671
  2. Anti-angiogenesis effect of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells.
    Kawamura et al.
    J.Antibiot.(Tokyo)., 2003;56:709
  3. Borrelidin modulates the alterntive splicing of VEGF in favour of anti-antiogenic isoforms.
    Woolard et al.
    Chem.Sci., 2011;:273
  4. Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis.
    Sidhu et al.
    ACS Med.Chem.Lett., 2015;6:1122

Have you used Borrelidin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information