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BRD 7552

Catalog #: 5230 Datasheet / COA / SDS

Discontinued Product

5230 has been discontinued.
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BRD 7552 | CAS No. 1137359-47-7 | Other Insulin and Insulin-like Receptor Products
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Description: PDX1 transcription factor inducer; increases insulin expression

Chemical Name: Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside

Purity: ≥98%

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Biological Activity

BRD 7552 is a PDX1 transcription factor inducer; up regulates PDX1 expression in both primary human islets and ductal cells. Induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. Increases insulin expression in PANC-1 cells, primary human islets and human duct-derived cells.

Technical Data

M.Wt:
711.63
Formula:
C33H33N3O15
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1137359-47-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small-molecule inducer of PDX1 expression identified by high-throughput screening.
    Yuan et al.
    Chem.Biol., 2013;20:1513

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