ATP non-competitive kinesin Eg5 inhibitor. Selectively inhibits microtubule-bound Eg5. Inhibits multiple myeloma cell growth (IC50
= 2.2 μ
Soluble to 50 mM in DMSO
Store at RT
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All Tocris products are intended for laboratory research use only.
Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors.
Chattopadhyay et al.
Cell Rep., 2015;10:755