BRD 9876

Name: BRD 9876
Brand: Tocris Bioscience
SKU: 5454

Catalog #: 5454 Datasheet / COA / SDS

Discontinued Product

5454 has been discontinued.

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BRD 9876 | CAS No. 32703-82-5 | Kinesin Inhibitors

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Description: ATP non-competitive kinesin Eg5 inhibitor

Chemical Name: 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile

Purity: ≥99%

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Product Details

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Biological Activity

ATP non-competitive kinesin Eg5 inhibitor. Selectively inhibits microtubule-bound Eg5. Inhibits multiple myeloma cell growth (IC₅₀ = 2.2 μM).

Technical Data

M.Wt:

234.3

Formula:

C₁₆H₁₄N₂

Solubility:

Soluble to 50 mM in DMSO

Purity:

≥99%

Storage:

Store at RT

CAS No:

32703-82-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors.
Chattopadhyay et al.
Cell Rep., 2015;10:755

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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