Catalog Number: 1207
Chemical Name: 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride
Biological Activity
A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.
Technical Data
  • M.Wt:
    443.42
  • Formula:
    C25H27ClN2O.HCl
  • Solubility:
    Soluble to 10 mM in DMSO and to 50 mM in ethanol
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1173022-77-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. 5-HT1-like receptors: a time to bid goodbye.
    Saxena et al.
    TiPS, 1998;19:311
  2. Stimulation of 5-HT1B receptors causes hypothermia in the rat.
    Hagan et al.
    Eur.J.Pharmacol., 1997;331:169
  3. SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.
    Price et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:312
  4. Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors.
    Schlicker et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:321
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BRL 15572 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
    Authors: Baillie Et al.
    World J Gastroenterol 2012;63:362

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