Catalog Number: 5817
Alternate Names: Iniparib
Chemical Name: 4-Iodo-3-nitrobenzamide
Biological Activity
PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo.
Technical Data
  • M.Wt:
    292.03
  • Formula:
    C7H5IN2O3
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    160003-66-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus.
    Ma W, Halweg CJ, Menendez D, Resnick MA.
    Proc Natl Acad Sci U S;109(17):6590-5 A.
  2. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.
    Liu et al.
    Clin.Cancer Res, 2011;18:510

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