BSI 201
Discontinued Product
5817 has been discontinued.
View all Poly(ADP-ribose) Polymerase Inhibitors products.
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Description: PARP-1 inhibitor
Alternative Names: Iniparib
Chemical Name: 4-Iodo-3-nitrobenzamide
Purity: ≥98%
Biological Activity
BSI 201 is a PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo.Technical Data
M.Wt:
292.03
Formula:
C7H5IN2O3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
160003-66-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus.
Ma W, Halweg CJ, Menendez D, Resnick MA.
Proc Natl Acad Sci U S;109(17):6590-5 A. -
Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.
Liu et al.
Clin.Cancer Res, 2011;18:510
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