PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro
. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo
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Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus.
Ma W, Halweg CJ, Menendez D, Resnick MA.
Proc Natl Acad Sci U S;109(17):6590-5 A.
Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.
Liu et al.
Clin.Cancer Res, 2011;18:510