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Burimamide oxalate

Catalog #: 1857 Datasheet / COA / SDS

Discontinued Product

1857 has been discontinued.
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Burimamide oxalate | CAS No. 163932-06-7 | Histamine H2 Receptor Antagonists
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Description: Mixed H2/H3 antagonist

Chemical Name: N-[4-(1H-Imidazol-4-yl)butyl]-N'-methylthiourea oxalate

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Biological Activity

Histamine H3/H2 receptor antagonist (Ki values are 0.07, 7.8 and 290 μM for H3, H2 and H1 receptors respectively). Displays partial agonist activity in SK-N-MC cells. Produces antinociceptive effects following intraventricular administration (ED50 = 183 nmol/mouse in hot-plate test).

Technical Data

M.Wt:
302.35
Formula:
C9H16N4S.C2H2O4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
163932-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Investigation into the role of histamine receptors in rodent antinociception.
    Lamberti et al.
    Pharmacol.Biochem.Behav., 1996;53:567
  2. Antinociceptive activity of derivatives of improgran and burimamide.
    Hough et al.
    Pharmacol.Biochem.Behav., 2000;65:61

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