Catalog Number: 3734
Chemical Name: 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
Biological Activity
Potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively).
Technical Data
  • M.Wt:
    252.27
  • Formula:
    C15H12N2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1104546-89-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
    Eltze et al.
    Mol.Pharmacol., 2008;74:1587
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BYK 204165 include:

1 Citations: Showing 1 - 1

  1. Cytotoxic effects of fascaplysin against small cell lung cancer cell lines.
    Authors: Hamilton
    Lab Chip 2014;12:1377

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