BYK 49187

Discontinued Product

3735 has been discontinued.
View all Poly(ADP-ribose) Polymerase Inhibitors products.
BYK 49187 | CAS No. 163120-31-8 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: PARP-1 and PARP-2 inhibitor

Chemical Name: 4,5-Dihydro-2-[4-(4-methyl-1H-imidazol-4-yl)-1-piperidinyl]-6H-imidazo[4,5,1-ij]quinolin-6-one

Purity: ≥98%

Product Details

Biological Activity

BYK 49187 is a PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro; reduces myocardial infarct size in vivo.

Technical Data

Soluble to 10 mM in DMSO and to 50 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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